The Latest on Uveal Melanoma Research and Clinical Trials: Updates from the Cure Ocular Melanoma (CURE OM) Science Meeting (2019)
| Autor: | Andrew E. Aplin, Anna Han, Kyleigh LiPira, Jane Mattei, Lauren Johnston, Richard D. Carvajal, Sapna Pradyuman Patel, Vivian Chua, Sara Selig |
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| Rok vydání: | 2021 |
| Předmět: |
Uveal Neoplasms
0301 basic medicine Oncology Cancer Research medicine.medical_specialty Ocular Melanoma MEDLINE Antineoplastic Agents Disease Medical Oncology Article 03 medical and health sciences 0302 clinical medicine Biological property Internal medicine Biomarkers Tumor medicine Humans Molecular Targeted Therapy Melanoma Societies Medical Clinical Trials as Topic BAP1 business.industry Computational Biology Cancer Congresses as Topic medicine.disease High-Throughput Screening Assays Clinical trial 030104 developmental biology 030220 oncology & carcinogenesis business |
| Zdroj: | Clin Cancer Res |
| ISSN: | 1557-3265 1078-0432 |
| Popis: | Uveal melanoma is a rare cancer in adults, but its treatment is one of the clinical unmet needs in the melanoma field. Metastatic disease develops in approximately 50% of patients and is associated with poor survival due to the lack of effective treatment options. It provides a paradigm for cancers that show evidence of aberrant G protein–coupled receptor signaling, tumor dormancy, and liver-selective metastatic tropism and are associated with the loss of the BAP1 tumor suppressor. At the Melanoma Research Foundation CURE OM Science Meeting at the Society for Melanoma Research Meeting held in Utah on November 20, 2019, clinicians and researchers presented findings from their studies according to three themes within uveal melanoma: (i) ongoing clinical trials, (ii) molecular determinants, and (iii) novel targets that could be translated into clinical trials. This meeting underscored the high interest in the uveal melanoma research field and the unmet need for effective treatment strategies for late-stage disease. Findings from ongoing clinical trials are promising, and multiple studies show how novel combinatorial strategies increase response rates. Novel targets and tumor vulnerabilities identified bioinformatically or through high-throughput screens also reveal new opportunities to target uveal melanoma. The future directions pursued by the uveal melanoma research field will likely have an impact on other cancer types that harbor similar genetic alterations and/or show similar biological properties. |
| Databáze: | OpenAIRE |
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