A cortical–hippocampal–cortical loop of information processing during memory consolidation
| Autor: | Elad Eban, Loren M. Frank, Gideon Rothschild |
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| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine Hippocampus Biology Hippocampal formation Auditory cortex Article 03 medical and health sciences 0302 clinical medicine Biological neural network Animals Learning Rats Long-Evans Wakefulness Memory Consolidation Auditory Cortex Neurons General Neuroscience Hippocampal replay Sleep in non-human animals Cortex (botany) 030104 developmental biology Memory consolidation Nerve Net Sleep Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Nature Neuroscience. 20:251-259 |
| ISSN: | 1546-1726 1097-6256 |
| DOI: | 10.1038/nn.4457 |
| Popis: | Hippocampal replay during sharp-wave ripple events (SWRs) is thought to drive memory consolidation in hippocampal and cortical circuits. Changes in neocortical activity can precede SWR events, but whether and how these changes influence the content of replay remains unknown. Here we show that during sleep there is a rapid cortical-hippocampal-cortical loop of information flow around the times of SWRs. We recorded neural activity in auditory cortex (AC) and hippocampus of rats as they learned a sound-guided task and during sleep. We found that patterned activation in AC precedes and predicts the subsequent content of hippocampal activity during SWRs, while hippocampal patterns during SWRs predict subsequent AC activity. Delivering sounds during sleep biased AC activity patterns, and sound-biased AC patterns predicted subsequent hippocampal activity. These findings suggest that activation of specific cortical representations during sleep influences the identity of the memories that are consolidated into long-term stores. |
| Databáze: | OpenAIRE |
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