Histologically benign metastatic meningioma: morphological and cytogenetic study. Case report
| Autor: | Fernando Talamantes, Concha López-Ginés, Pedro Roldán, José Barberá, Miguel Pérez-Bacete, Miguel Cerdá-Nicolás |
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| Rok vydání: | 2003 |
| Předmět: |
Male
medicine.medical_specialty Pathology Monosomy Lung Neoplasms Metastasis Meningioma Meningeal Neoplasms Medicine Humans Aged medicine.diagnostic_test business.industry Splenic Neoplasms Metastatic Meningioma Liver Neoplasms Cytogenetics medicine.disease Magnetic Resonance Imaging Kidney Neoplasms Benign Meningioma Cytogenetic Analysis business Chromosome 22 Fluorescence in situ hybridization |
| Zdroj: | Journal of neurosurgery. 98(1) |
| ISSN: | 0022-3085 |
| Popis: | ✓ The authors report on a 75-year-old man with histologically benign fibroblastic meningioma metastasizing to the lung, liver, spleen, and kidney. The original tumor exhibited a complex karyotype involving different structural and numerical anomalies associated with monosomy of chromosome 22. The implication of chromosome 1p36 was confirmed by fluorescence in situ hybridization in most interphase nuclei. Metastases occurred 4 months after incomplete resection with prior therapeutic embolization. The recurrent tumor in turn displayed anaplastic features and an increased Ki-67 labeling index. Genetic alterations in such morphologically benign meningiomas have been implicated in the malignant development and progression of these tumors. |
| Databáze: | OpenAIRE |
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