Stress-Tolerant Yeasts: Opportunistic Pathogenicity Versus Biocontrol Potential
Autor: | Nina Gunde-Cimerman, Anja Černoša, Cene Gostinčar, Janja Zajc |
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Rok vydání: | 2018 |
Předmět: |
0301 basic medicine
Thermotolerance Siderophore siderophore lcsh:QH426-470 Biological pest control Aureobasidium melanogenum Human pathogen Rhodotorula mucilaginosa Article biofilm Microbiology Fungal Proteins 03 medical and health sciences 0302 clinical medicine Yeasts Genetics Genetics (clinical) biology Virulence stress tolerance opportunistic pathogen Biofilm protease biology.organism_classification melanin Aureobasidium pullulans biocontrol agent lcsh:Genetics Oxidative Stress secretome 030104 developmental biology 030220 oncology & carcinogenesis Biofilms CAZy oligotrophism Exophiala dermatitidis |
Zdroj: | Genes Volume 10 Issue 1 Genes, Vol 10, Iss 1, p 42 (2019) |
ISSN: | 2073-4425 |
Popis: | Stress-tolerant fungi that can thrive under various environmental extremes are highly desirable for their application to biological control, as an alternative to chemicals for pest management. However, in fungi, the mechanisms of stress tolerance might also have roles in mammal opportunism. We tested five species with high biocontrol potential in agriculture (Aureobasidium pullulans, Debayomyces hansenii, Meyerozyma guilliermondii, Metschnikowia fructicola, Rhodotorula mucilaginosa) and two species recognized as emerging opportunistic human pathogens (Exophiala dermatitidis, Aureobasidium melanogenum) for growth under oligotrophic conditions and at 37 °C, and for tolerance to oxidative stress, formation of biofilms, production of hydrolytic enzymes and siderophores, and use of hydrocarbons as sole carbon source. The results show large overlap between traits desirable for biocontrol and traits linked to opportunism (growth under oligotrophic conditions, production of siderophores, high oxidative stress tolerance, and specific enzyme activities). Based on existing knowledge and these data, we suggest that oligotrophism and thermotolerance together with siderophore production at 37 °C, urease activity, melanization, and biofilm production are the main traits that increase the potential for fungi to cause opportunistic infections in mammals. These traits should be carefully considered when assessing safety of potential biocontrol agents. |
Databáze: | OpenAIRE |
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