Neutrophils mitigate the systemic host response during endotoxemia in mice
| Autor: | Arie J. Hoogendijk, Louis Boon, Anne Jan van der Meer, Tom van der Poll, Alex F. de Vos, Sacha Zeerleder, Chao Ding |
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| Přispěvatelé: | Graduate School, ACS - Pulmonary hypertension & thrombosis, AII - Inflammatory diseases, Experimental Immunology, Center of Experimental and Molecular Medicine, Clinical Haematology, Infectious diseases, 01 Internal and external specialisms |
| Rok vydání: | 2018 |
| Předmět: |
Lipopolysaccharides
0301 basic medicine Chemokine Lipopolysaccharide Neutrophils medicine.medical_treatment Immunology Host response chemokines 610 Medicine & health Inflammation Mice 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Cell Wall Gram-Negative Bacteria medicine Animals Immunology and Allergy Host Microbial Interactions biology Chemistry neutrophil Original Articles cytokines Endotoxemia Mice Inbred C57BL Vascular endothelium 030104 developmental biology Cytokine Coagulation inflammation Plasma concentration biology.protein Original Article Female Endothelium Vascular medicine.symptom Biomarkers 030215 immunology |
| Zdroj: | van der Meer, Anne Jan; Ding, Chao; Hoogendijk, Arie Johan; de Vos, Alex F; Boon, Louis; Zeerleder, Sacha S.; van der Poll, Tom (2019). Neutrophils mitigate the systemic host response during endotoxemia in mice. Immunology, 156(3), pp. 277-281. Wiley-Blackwell 10.1111/imm.13026 Immunology Immunology, 156(3), 277-281. Wiley-Blackwell |
| ISSN: | 0019-2805 |
| DOI: | 10.1111/imm.13026 |
| Popis: | Summary Recent studies have suggested that neutrophils can exert anti‐inflammatory effects. To determine the role of neutrophils in the acute response to lipopolysaccharide (LPS), a component of the Gram‐negative bacterial cell wall, we challenged neutrophil‐depleted and control mice with LPS and analyzed the plasma concentrations of biomarkers indicative of the cytokine and chemokine network, activation of coagulation and the vascular endothelium, and cellular injury. We here show that neutrophils serve an anti‐inflammatory role upon LPS administration, as reflected by sustained elevations of multiple cytokines and chemokines, and enhanced release of nucleosomes in mice depleted of neutrophils, compared with control mice. |
| Databáze: | OpenAIRE |
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