Peripheral Neuropathy Presents Similar Symptoms and Pathological Changes in Both High-Fat Diet and Pharmacologically Induced Pre- and Diabetic Mouse Models
| Autor: | K. Wasowicz, Joanna Wojtkiewicz, A. Pomianowski, Tomasz Antonowski, Agnieszka Korytko, Judyta K. Juranek, Kamila Zglejc-Waszak, Julia Jaroslawska |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Diabetic neuropathy endocrine system diseases Science sciatic nerve Type 2 diabetes streptozotocin General Biochemistry Genetics and Molecular Biology Article Internal medicine Diabetes mellitus Medicine diabetic mouse models Ecology Evolution Behavior and Systematics business.industry diabetic peripheral neuropathy Paleontology nutritional and metabolic diseases medicine.disease Streptozotocin Endocrinology Peripheral neuropathy medicine.anatomical_structure high-fat diet Space and Planetary Science Peripheral nervous system Sciatic nerve business Sensory nerve medicine.drug |
| Zdroj: | Life, Vol 11, Iss 1267, p 1267 (2021) Life Volume 11 Issue 11 |
| ISSN: | 2075-1729 |
| Popis: | The objective of the study was to compare the effects of experimentally induced type 1 or type 2 diabetes (T1D or T2D) on the functional, structural and biochemical properties of mouse peripheral nerves. Eight-week-old C57BL/6 mice were randomly assigned into three groups, including the control (CTRL, chow-fed), STZ (streptozotocin (STZ)-injected), and HFD (high-fat diet (HFD)-fed) group. After 18-weeks of experimental treatment, HFD mice had higher body weights and elevated levels of plasma lipids, while STZ mice developed hyperglycemia. STZ-treated mice, after an extended period of untreated diabetes, developed motor and sensory nerve conduction-velocity deficits. Moreover, relative to control fibers, pre- and diabetic axons were lower in number and irregular in shape. Animals from both treatment groups manifested a pronounced overexpression of nNOS and a reduced expression of SOD1 proteins in the sciatic nerve, indicating oxidative–nitrosative stress and ineffective antioxidant protection in the peripheral nervous system of these mice. Collectively, STZ- and HFD-treated mice revealed similar characteristics of peripheral nerve damage, including a number of morphological and electrophysiological pathologies in the sciatic nerve. While hyperglycemia is a large component of diabetic neuropathy pathogenesis, the non-hyperglycemic effects of diabetes, including dyslipidemia, may also be of importance in the development of this condition. |
| Databáze: | OpenAIRE |
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