Prognostic significance of propofol-based intravenous anesthesia in early-stage lung cancer surgery
| Autor: | Satoshi Shiono, Makoto Endoh, Seiji Takaoka, Kazuki Hayasaka, Satoshi Miyata, Yoshinori Okada |
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| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Lung Neoplasms Gastroenterology 03 medical and health sciences 0302 clinical medicine Surgical oncology Carcinoma Non-Small-Cell Lung Internal medicine medicine Humans Stage (cooking) Pneumonectomy Lung cancer Propofol Aged Neoplasm Staging Lung cancer surgery INHA business.industry General Medicine Middle Aged Prognosis medicine.disease Survival Rate Intravenous anesthesia 030220 oncology & carcinogenesis Multivariate Analysis Anesthetic Anesthesia Intravenous Female 030211 gastroenterology & hepatology Surgery Anesthesia Inhalation business medicine.drug |
| Zdroj: | Surgery Today. 51:1300-1308 |
| ISSN: | 1436-2813 0941-1291 |
| Popis: | The purpose of this study was to assess whether the anesthetic type is associated with the prognosis of pathological stage I non-small cell lung cancer (NSCLC). Clinicopathological data from 431 consecutive patients who underwent lobectomy for NSCLC between 2010 and 2016 were collected. Patients were classified into groups according to the type of anesthesia: propofol-based total intravenous anesthesia (TIVA) or inhalation anesthesia (INHA). We investigated the prognostic differences between these two groups. A total of 72 patients in the TIVA group and 158 patients in the INHA group were eligible for the analysis. Recurrence was observed in 4 (5.6%) patients in the TIVA group and 19 (12.0%) patients in the INHA group (P = 0.159), and all-cause death occurred in 4 (5.6%) patients in the TIVA group and 24 (15.2%) patients in the INHA group (P = 0.049). The 5-year recurrence-free survival (RFS) and overall survival rates of the TIVA/INHA groups were 91.7%/77.4% and 94.4%/83.5%, respectively. TIVA was associated with a significantly better prognosis. A multivariable analysis of factors associated with RFS revealed that the type of anesthesia as a significant prognostic factor (P = 0.047). Propofol-based TIVA was associated with a better prognosis in comparison to INHA in patients with surgically resected pathological stage I NSCLC. |
| Databáze: | OpenAIRE |
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