Fully Supramolecular Polyrotaxanes as Biphase Drug Delivery Systems
| Autor: | Mohsen Adeli, Leila Khosravi far, Abdolhossien Massoudi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
chemistry.chemical_classification
Polymers and Plastics Cyclodextrin Article Subject Hydrogen bond Supramolecular chemistry Polyethylene glycol Conjugated system lcsh:Chemical technology Combinatorial chemistry Thymine chemistry.chemical_compound chemistry Drug delivery Organic chemistry Non-covalent interactions lcsh:TP1-1185 |
| Zdroj: | International Journal of Polymer Science, Vol 2014 (2014) |
| ISSN: | 1687-9422 |
| DOI: | 10.1155/2014/829474 |
| Popis: | Pseudopolyrotaxanes (PPR) consisting ofα-cyclodextrin rings and polyethylene glycol axes with end thymine groups have been synthesized and characterized successfully. Fluorescein (Fl) as a model drug was conjugated to the hydroxyl functional groups of cyclodextrin rings of PPR via ester bonds and PPR-Fl as the primary drug delivery system was obtained. Finally PPR-Fl was capped by hydrogen bonds between end thymine groups and a suitable complementary molecule such as polycitric acid, citric acid, or adenine. The aim of this work was to control the release of the fluorescein-cyclodextrin (Fl-CD) conjugates, as the secondary drug delivery systems, from PPR-Fl by controlling the noncovalent interactions between stoppers and thymine end groups. It was found that the rate of release of the Fl-CD from PPR-Fl could be controlled by pH and the ratio of citric acid or adenine to the PPR-Fl. |
| Databáze: | OpenAIRE |
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