Modulation of gene expression in Kaposi’s sarcoma-associated herpesvirus-infected lymphoid and epithelial cells
| Autor: | Lisa Fusetti, Giulia Ciccarese, Francesco Broccolo, B Matteoli, Luca Ceccherini-Nelli, Susanna Esposito, A. Scaccino, Francesco Drago, Francesco Formica, Massimo Oggioni |
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| Přispěvatelé: | Matteoli, B, Broccolo, F, Oggioni, M, Scaccino, A, Formica, F, Ciccarese, G, Drago, F, Fusetti, L, Esposito, S, Ceccherini Nelli, L |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Cell type Cell Kaposi's sarcoma Inflammation Biology medicine.disease_cause medicine.disease 03 medical and health sciences 030104 developmental biology medicine.anatomical_structure Virology Gene expression Immunology gene expression medicine Kaposi's sarcoma-associated herpesvirus medicine.symptom Signal transduction Gene HHV-8 |
| Zdroj: | Future Virology. 11:619-629 |
| ISSN: | 1746-0808 1746-0794 |
| DOI: | 10.2217/fvl-2016-0063 |
| Popis: | Aim: To evaluate the gene expression changes that occur soon after the active infection of two susceptible cell types with human herpesvirus 8 (HHV-8). Materials & methods: The expression profile of 282 human genes involved in the inflammatory process was investigated in HHV-8 A1 or C3 subtype-infected and mock-infected human epithelial cells and lymphoid cells. Results: The HHV-8-induced transcriptional profiles in the epithelial and lymphoid cells were very different. A robust increase in the expression was found in genes belonging to different categories, especially the categories of inflammation response and signal transduction. Conclusion: These results indicate that during early infection, HHV-8 induces a variety of cell type-specific processes, thus providing infection signatures useful as potential targets for therapeutic intervention. |
| Databáze: | OpenAIRE |
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