Cardiac Autonomic Functions in Obese Children
| Autor: | Rusen Dundaroz, Mehmet Boyraz, Mehmet Emre Tascilar, Oben Baysan, Mehmet Yokuşoğlu, Cem Köz |
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| Přispěvatelé: | İŞCAN, AKIN |
| Rok vydání: | 2011 |
| Předmět: |
Male
medicine.medical_specialty Adolescent Endocrinology Diabetes and Metabolism Cardiac Autonomic Functions Autonomic Nervous System Childhood obesity Endocrinology Insulin resistance Heart Conduction System Heart Rate Internal medicine Heart rate medicine Humans Heart rate variability Obesity Child cardiac autonomic function power spectral analysis business.industry heart rate variability Case-control study medicine.disease time-domain analysis Autonomic nervous system Case-Control Studies Pediatrics Perinatology and Child Health Electrocardiography Ambulatory Cardiology Female Original Article Insulin Resistance business Body mass index |
| Zdroj: | Journal of Clinical Research in Pediatric Endocrinology |
| ISSN: | 1308-5727 |
| Popis: | Objective: The autonomic nervous system is assumed to have a role in the pathophysiology of obesity. In this study, we evaluated the autonomic system by measuring heart rate variability (HRV) in obese children. Methods: Thirty-two obese and 30 healthy children (mean ages: 11.6±2.0 years and 11.0±2.9 years, respectively) were enrolled in the study. Obesity was defined as a body mass index higher than 97th percentile for age- and gender-specific reference values. All participants were free of any disease and none of them was receiving any medication. Twenty-four-hour ambulatory electrocardiographic recordings were obtained and the time-domain and frequency-domain indices of HRV were analyzed. The study group was evaluated with respect to insulin resistance by HOMA-IR values. Results: A significant decrease in calculated HRV variables was observed in obese children as compared to controls. The HRV alteration was found in both time-domain and frequency-domain parameters. The subgroup analysis of the study group revealed a significant decrease in all investigated HRV parameters in the insulin-resistant obese children compared to the non-insulin-resistant obese ones. Conclusions: Our results indicate that HRV is decreased in obese children, which implies parasympathetic withdrawal and sympathetic predominance. A marked decrease in HRV was observed in insulin-resistant obese children compared to their non-insulin-resistant counterparts. We propose that autonomic imbalance pertaining especially to insulin resistance may be involved in the pathogenesis of obesity in pediatric patients Conflict of interest:None declared. |
| Databáze: | OpenAIRE |
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