Gene duplication in bovine brain myelin proteolipid and homology with related proteins
| Autor: | Marjorie B. Lees, Richard A. Laursen, Mohammed Samiullah |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
Proteolipid protein 1
Gene duplication Proteolipids Protein subunit Biophysics Nerve Tissue Proteins Biochemistry Homology (biology) Structure-Activity Relationship Myelin immune system diseases Structural Biology Genetics medicine Animals Amino Acid Sequence Molecular Biology Myelin proteolipid Peptide sequence Myelin Sheath biology fungi Brain Cell Biology nervous system diseases Myelin basic protein medicine.anatomical_structure Genes nervous system Membrane protein biology.protein ATP synthase Cattle lipids (amino acids peptides and proteins) Po glycoprotein |
| Zdroj: | FEBS Letters. 161:71-74 |
| ISSN: | 0014-5793 |
| DOI: | 10.1016/0014-5793(83)80732-7 |
| Popis: | Analysis of the amino acid sequence of bovine brain myelin proteolipid reveals not only extensive internal homology, but also homology with portions of the myelin basic protein, the peripheral nerve myelin protein, Po, and with the small proteolipid subunit of mitochondrial ATP synthase. These results suggest that the myelin proteolipid gene has been constructed from a small number of genetic elements, and that these elements are also found in non-myelin proteins. Furthermore, the proteolipid appears to have evolved by acquisition of elements from a ‘gene pool’ over a period of time, rather than by a simple duplication mechanism. |
| Databáze: | OpenAIRE |
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