MicroRNAs in Neurocognitive Dysfunctions: New Molecular Targets for Pharmacological Treatments?
| Autor: | Patrick Baril, Wissem Deraredj Nadim, Viorel Simion, Chantal Pichon, Hélène Bénédetti, Séverine Morisset-Lopez |
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| Přispěvatelé: | Centre de biophysique moléculaire (CBM), Université d'Orléans (UO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC) |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
[SDV]Life Sciences [q-bio] Disease Bibliographic/statistics & numerical data 0302 clinical medicine Signal Transduction/drug effects Antagomirs/pharmacology/*therapeutic use Neurodegenerative Diseases/drug therapy Pharmacology (medical) Neuronal Plasticity Neurogenesis Neuronal Plasticity/drug effects Cognition MicroRNA Neurodegenerative Diseases General Medicine Gene Expression Regulation/*drug effects/physiology 3. Good health Psychiatry and Mental health psychiatric disorders Neurology Schizophrenia Cognition Disorders/*drug therapy/genetics LTP Signal Transduction Biology Article 03 medical and health sciences Databases Cognitive dysfunction microRNA medicine Animals Humans Pharmacology MicroRNAs/antagonists & inhibitors/genetics/*metabolism Antagomirs medicine.disease Databases Bibliographic signaling pathways MicroRNAs 030104 developmental biology Gene Expression Regulation Synaptic plasticity Autism Neurology (clinical) Cognition Disorders Neuroscience Neurocognitive 030217 neurology & neurosurgery |
| Zdroj: | Current Neuropharmacology Current Neuropharmacology, Bentham Science Publishers, 2017, 15 (2), pp.260-275. ⟨10.2174/1570159X14666160709001441⟩ |
| ISSN: | 1875-6190 1570-159X |
| DOI: | 10.2174/1570159X14666160709001441⟩ |
| Popis: | International audience; BACKGROUND: Neurodegenerative and cognitive disorders are multifactorial diseases (i.e., involving neurodevelopmental, genetic, age or environmental factors) characterized by an abnormal development that affects neuronal function and integrity. Recently, an increasing number of studies revealed that the dysregulation of microRNAs (miRNAs) may be involved in the etiology of cognitive disorders as Alzheimer, Parkinson, and Huntington's diseases, Schizophrenia and Autism spectrum disorders.METHODS: From an extensive search in bibliographic databases of peer-reviewed research literature, we identified relevant published studies related to specific key words such as memory, cognition, neurodegenerative disorders, neurogenesis and miRNA. We then analysed, evaluated and summerized scientific evidences derived from these studies.RESULTS: We first briefly summarize the basic molecular events involved in memory, a process inherent to cognitive disease, and then describe the role of miRNAs in neurodevelopment, synaptic plasticity and memory. Secondly, we provide an overview of the impact of miRNA dysregulation in the pathogenesis of different neurocognitive disorders, and lastly discuss the feasibility of miRNA-based therapeutics in the treatment of these disorders.CONCLUSION: This review highlights the molecular basis of neurodegenerative and cognitive disorders by focusing on the impact of miRNAs dysregulation in these pathological phenotypes. Altogether, the published reports suggest that miRNAs-based therapy could be a viable therapeutic alternative to current treatment options in the future. |
| Databáze: | OpenAIRE |
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