Multiband mucosectomy versus endoscopic submucosal dissection and endoscopic submucosal excavation for GI submucosal tumors: short and long term follow-up
Autor: | Christoph J. Auernhammer, Tong-Hai Chai, Rong-Lian Du, Xi-Feng Jin, Wei Gai, Ling Li |
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Jazyk: | angličtina |
Rok vydání: | 2019 |
Předmět: |
0301 basic medicine
Male Cancer Research medicine.medical_specialty Esophageal Mucosa Endoscopic Mucosal Resection Endoscopic submucosal excavation (ESE) Long term follow up Perforation (oil well) Operative Time Complete resection lcsh:RC254-282 03 medical and health sciences 0302 clinical medicine Postoperative Complications Genetics medicine Upper gastrointestinal Humans Endoscopic submucosal dissection (ESD) Gastrointestinal Neoplasms Retrospective Studies business.industry En bloc resection Endoscopic submucosal dissection Submucosal tumours (SMTs) Middle Aged lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens Surgery Dissection 030104 developmental biology Treatment Outcome Oncology Gastric Mucosa 030220 oncology & carcinogenesis Gastrointestinal (GI) Female Multiband mucosectomy (MBM) Neoplasm Recurrence Local business Major bleeding Research Article Follow-Up Studies |
Zdroj: | BMC Cancer, Vol 19, Iss 1, Pp 1-8 (2019) BMC Cancer |
ISSN: | 1471-2407 |
DOI: | 10.1186/s12885-019-6100-8 |
Popis: | Aims To evaluate the short- and long-term outcomes of 3 different endoscopic dissection techniques for upper gastrointestinal (GI) submucosal tumours (SMTs). Methods Data for 135 patients withGI SMTs who underwent multiband mucosectomy (MBM), endoscopic submucosal dissection (ESD), or endoscopic submucosal excavation (ESE) were retrospectively assessed. The en bloc resection rate, endoscopic complete resection rate, operation time, potential complications and local recurrence rate were compared. Results No significant differences were observed in the rate of endoscopic complete resections and pathologic complete resections among the three groups. For SMTs > 15 mm in width, the lowest en bloc resection rate was found for MBM (P = 0.000). MBM was also associated with the shortest procedure time, lowest perforation rate and lowest rate of major bleeding. ESE was the most effective procedure for muscularis propria (MP) lesions but was associated with the longest operation time (P 0.05). No differences were observed in 4-year local recurrence rates among the groups (P = 0.945). Conclusions MBM is a simple and effective method for the treatment of small SMTs and achieves clinical success rates similar to those of ESD and ESE. However, ESD and ESE are preferable for larger and deep lesions and are associated with a longer operation time. Nonetheless, all 3 techniques resulted in a low 4-year local recurrence rate. Large-scale randomized clinical trials are needed to further investigate these results. |
Databáze: | OpenAIRE |
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