Multiband mucosectomy versus endoscopic submucosal dissection and endoscopic submucosal excavation for GI submucosal tumors: short and long term follow-up

Autor: Christoph J. Auernhammer, Tong-Hai Chai, Rong-Lian Du, Xi-Feng Jin, Wei Gai, Ling Li
Jazyk: angličtina
Rok vydání: 2019
Předmět:
0301 basic medicine
Male
Cancer Research
medicine.medical_specialty
Esophageal Mucosa
Endoscopic Mucosal Resection
Endoscopic submucosal excavation (ESE)
Long term follow up
Perforation (oil well)
Operative Time
Complete resection
lcsh:RC254-282
03 medical and health sciences
0302 clinical medicine
Postoperative Complications
Genetics
medicine
Upper gastrointestinal
Humans
Endoscopic submucosal dissection (ESD)
Gastrointestinal Neoplasms
Retrospective Studies
business.industry
En bloc resection
Endoscopic submucosal dissection
Submucosal tumours (SMTs)
Middle Aged
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Surgery
Dissection
030104 developmental biology
Treatment Outcome
Oncology
Gastric Mucosa
030220 oncology & carcinogenesis
Gastrointestinal (GI)
Female
Multiband mucosectomy (MBM)
Neoplasm Recurrence
Local

business
Major bleeding
Research Article
Follow-Up Studies
Zdroj: BMC Cancer, Vol 19, Iss 1, Pp 1-8 (2019)
BMC Cancer
ISSN: 1471-2407
DOI: 10.1186/s12885-019-6100-8
Popis: Aims To evaluate the short- and long-term outcomes of 3 different endoscopic dissection techniques for upper gastrointestinal (GI) submucosal tumours (SMTs). Methods Data for 135 patients withGI SMTs who underwent multiband mucosectomy (MBM), endoscopic submucosal dissection (ESD), or endoscopic submucosal excavation (ESE) were retrospectively assessed. The en bloc resection rate, endoscopic complete resection rate, operation time, potential complications and local recurrence rate were compared. Results No significant differences were observed in the rate of endoscopic complete resections and pathologic complete resections among the three groups. For SMTs > 15 mm in width, the lowest en bloc resection rate was found for MBM (P = 0.000). MBM was also associated with the shortest procedure time, lowest perforation rate and lowest rate of major bleeding. ESE was the most effective procedure for muscularis propria (MP) lesions but was associated with the longest operation time (P 0.05). No differences were observed in 4-year local recurrence rates among the groups (P = 0.945). Conclusions MBM is a simple and effective method for the treatment of small SMTs and achieves clinical success rates similar to those of ESD and ESE. However, ESD and ESE are preferable for larger and deep lesions and are associated with a longer operation time. Nonetheless, all 3 techniques resulted in a low 4-year local recurrence rate. Large-scale randomized clinical trials are needed to further investigate these results.
Databáze: OpenAIRE
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