Amygdala and whole brain activity to emotional faces distinguishes major depressive disorder and bipolar disorder
| Autor: | Jorge R. C. Almeida, Dina M. Kronhaus, Mary L. Phillips, Matthew T. Keener, Jay C. Fournier |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Adult
Male medicine.medical_specialty Bipolar Disorder Brain activity and meditation media_common.quotation_subject Emotions Anger behavioral disciplines and activities Amygdala Lateralization of brain function Article Young Adult Neuroimaging mental disorders medicine Image Processing Computer-Assisted Humans Bipolar disorder Psychiatry Biological Psychiatry media_common Analysis of Variance Depressive Disorder Major medicine.diagnostic_test Brain medicine.disease Magnetic Resonance Imaging Facial Expression Oxygen Psychiatry and Mental health medicine.anatomical_structure Pattern Recognition Visual Major depressive disorder Female Psychology Functional magnetic resonance imaging Photic Stimulation Clinical psychology |
| Popis: | Objectives It can be clinically difficult to distinguish depressed individuals with bipolar disorder (BD) and major depressive disorder (MDD). To examine potential biomarkers of difference between the two disorders, the current study examined differences in the functioning of emotion-processing neural regions during a dynamic emotional faces task. Methods During functional magnetic resonance imaging, healthy control adults (HC) (n = 29) and depressed adults with MDD (n = 30) and BD (n = 22) performed an implicit emotional-faces task in which they identified a color label superimposed on neutral faces that dynamically morphed into one of four emotional faces (angry, fearful, sad, happy). We compared neural activation between the groups in an amygdala region-of-interest and at the whole-brain level. Results Adults with MDD showed significantly greater activity than adults with BD in the left amygdala to the anger condition (p = 0.01). Results of whole-brain analyses (at p < 0.005, k ≥ 20) revealed that adults with BD showed greater activity to sad faces in temporoparietal regions, primarily in the left hemisphere, whereas individuals with MDD demonstrated greater activity than those with BD to displays of anger, fear, and happiness. Many of the observed BD–MDD differences represented abnormalities in functioning compared to HC. Conclusions We observed a dissociation between depressed adults with BD and MDD in the processing of emerging emotional faces. Those with BD showed greater activity during mood-congruent (i.e., sad) faces, whereas those with MDD showed greater activity for mood-incongruent (i.e., fear, anger, and happy) faces. Such findings may reflect markers of differences between BD and MDD depression in underlying pathophysiological processes. |
| Databáze: | OpenAIRE |
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