Effect of Temperature on the Contractile Response of Isolated Rat Small Intestine to Acetylcholine and KCl: Calcium Dependence
| Autor: | G Sabeur |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
medicine.medical_specialty
Physiology chemistry.chemical_element Isometric exercise In Vitro Techniques Calcium Calcium in biology Potassium Chloride Tonic (physiology) Isometric Contraction Physiology (medical) Internal medicine Intestine Small medicine Animals Drug Interactions Rats Wistar Chemistry Muscle Smooth General Medicine Smooth muscle contraction Acetylcholine Small intestine Culture Media Rats Cold Temperature medicine.anatomical_structure Endocrinology Female medicine.symptom medicine.drug Muscle contraction |
| Zdroj: | Archives of Physiology and Biochemistry. 104:220-228 |
| ISSN: | 1744-4160 1381-3455 |
| DOI: | 10.1076/apab.104.2.220.12891 |
| Popis: | The influence of temperature on phasic and tonic components of isometric tension of the isolated rat small intestine was investigated at two temperatures (15 degrees C and 21 degrees C) where spontaneous movements were not evident. Warming did not shift acetylcholine-response curve whereas it enhanced the amplitude of maximal tension. The rate of tension development varied with acetylcholine concentration and increased with temperature. Warming enhanced and accelerated responses to single doses of high KCl. The effect of temperature on acetylcholine responses was mimicked by lowering calcium concentration in the bathing medium but in zero-calcium medium responses were higher at 21 degrees C than at 33 degrees C. Discussion of previous reports underlines that opposite observations on the effect of temperature on smooth muscle contraction are mainly explained by experimental protocols. In turn, it is suggested that the obtained effects of temperature might be related to the regulation of intracellular calcium concentration. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|