Trajectories of Childhood Adversity and Type 1 Diabetes: A Nationwide Study of One Million Children
| Autor: | Marit E. Jørgensen, Naja Hulvej Rod, Jessica Bengtsson, Jannet Svensson, Bendix Carstensen, Andreas Rieckmann |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Parents Research design Endocrinology Diabetes and Metabolism 030209 endocrinology & metabolism Parental chromosome Danish Fight-or-flight response 03 medical and health sciences 0302 clinical medicine Adverse Childhood Experiences Risk Factors Diabetes mellitus Internal Medicine medicine Humans 030212 general & internal medicine Child Advanced and Specialized Nursing Type 1 diabetes business.industry Incidence Incidence (epidemiology) medicine.disease language.human_language Diabetes Mellitus Type 1 Register data language Female business Demography |
| Zdroj: | Bengtsson, J, Rieckmann, A, Carstensen, B, Svensson, J, Jørgensen, M E & Rod, N H 2021, ' Trajectories of Childhood Adversity and Type 1 Diabetes : A Nationwide Study of One Million Children ', Diabetes Care, vol. 44, no. 3, pp. 740-747 . https://doi.org/10.2337/dc20-1130 |
| ISSN: | 1935-5548 0149-5992 |
| DOI: | 10.2337/dc20-1130 |
| Popis: | OBJECTIVE Experiencing adversities in childhood may increase the risk of type 1 diabetes through hyperactivation of the stress response system, but the empirical evidence is conflicting. We aim to describe the age-specific incidence of type 1 diabetes for males and females separately in five predefined groups covering the most common trajectories of adversity among Danish children. RESEARCH DESIGN AND METHODS We included all 1,081,993 children without parental type 1 diabetes born in Denmark from 1980 to 1998. We used register data to estimate age-specific incidence rates of type 1 diabetes in five trajectory groups of adversity characterized by 1) low adversity, 2) early life material deprivation, 3) persistent material deprivation, 4) loss or threat of loss in the family, and 5) cumulative high adversity. All analyses were stratified by sex. RESULTS In total, 5,619 people developed type 1 diabetes before 2016. We found only minor differences when comparing the incidence rates of type 1 diabetes between the trajectory groups. The only clear exceptions were in the high versus low adversity group, in which males had a higher incidence of type 1 diabetes in childhood ( CONCLUSIONS Childhood adversities were generally not associated with age-specific incidence of type 1 diabetes except among those exposed to a very high and increasing annual rate of childhood adversities. Differences between highly exposed males and females seem to depend on age at onset of type 1 diabetes. |
| Databáze: | OpenAIRE |
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