Association between ideal cardiovascular health metrics and risk of cardiovascular events or mortality: A meta-analysis of prospective studies
| Autor: | Leilei Guo, Shangshu Zhang |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
Health Status Clinical Investigations 030204 cardiovascular system & hematology Global Health 03 medical and health sciences 0302 clinical medicine Risk Factors Internal medicine medicine Humans 030212 general & internal medicine Prospective Studies Prospective cohort study Stroke Exercise business.industry Incidence General Medicine medicine.disease Confidence interval Survival Rate Blood pressure Cardiovascular Diseases Relative risk Meta-analysis Cohort Observational study Cardiology and Cardiovascular Medicine business |
| Zdroj: | Clinical cardiology. 40(12) |
| ISSN: | 1932-8737 |
| Popis: | Background Observational studies evaluating the relationship between ideal cardiovascular health (CVH) metrics and risk of cardiovascular (CV) events and mortality yielded inconsistent results. Hypothesis Improvement in CVH metrics can result in substantial reductions in the risk of cardiovascular disease (CVD), stroke, and mortality. Methods We examined associations between ideal CVH metrics and CV events and mortality by conducting a meta-analysis of data from prospective cohort studies identified by searching PubMed and Web of Science from their inception to February 2017 and reviewing the reference lists of the retrieved articles. Results Thirteen prospective studies involving a total of 193 126 cohort members were included in this meta-analysis. When comparing the most to the least category of ideal CVH metrics, the overall relative risks (RRs) were 0.54 (95% confidence interval [CI]: 0.41-0.69) for all-cause mortality, 0.30 (95% CI: 0.18-0.51) for CV mortality, 0.22 (95% CI: 0.11-0.42) for CVD, and 0.33 (95% CI: 0.20-0.55) for stroke, respectively. A linear dose-response relationship was seen in all-cause and CV mortality. The risk decreased by 11% and 19% for each increase in ideal CVH metrics. For the analyses of ideal health status in relation to all-cause and CV mortality, significant results were obtained from smoking, diet, physical activity, plasma glucose levels, and blood pressure. Conclusions Ideal CVH status, or even 1 point increase in CVH metrics, can result in substantial reductions in the risk of CVD, stroke, and mortality. Improving metrics of smoking, diet, physical activity, plasma glucose levels, and blood pressure will achieve the highest benefits. |
| Databáze: | OpenAIRE |
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