IL-13 may be involved in the development of CAD via different mechanisms under different conditions in a Chinese Han population
| Autor: | Jiao Jiao, Hong Song Zhang, Peng Yun Wang, Qian Wen Chen, Yuhua Liao, Qing Kenneth Wang, Jiang Tao Dong, Ying Chao Zhou, Tian Xie, Shao Fang Nie, Xiang Cheng, Chengqi Xu, Tingting Tang, Ni Xia, Zhi Peng Zeng, Fan Wang, Ling Feng Zha, Xin Tu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Oncology Adult Male medicine.medical_specialty China Population lcsh:Medicine CAD Single-nucleotide polymorphism Comorbidity Coronary Artery Disease 030204 cardiovascular system & hematology Logistic regression Polymorphism Single Nucleotide Risk Assessment Article Linkage Disequilibrium Coronary artery disease 03 medical and health sciences 0302 clinical medicine Asian People Internal medicine medicine Odds Ratio Humans Genetic Predisposition to Disease education lcsh:Science Alleles Genetic Association Studies education.field_of_study Multidisciplinary Interleukin-13 business.industry Haplotype lcsh:R Middle Aged medicine.disease 030104 developmental biology Case-Control Studies Interleukin 13 Cohort lcsh:Q Female business |
| Zdroj: | Scientific Reports Scientific Reports, Vol 8, Iss 1, Pp 1-8 (2018) |
| ISSN: | 2045-2322 |
| Popis: | Interleukin-13 (IL-13) has important functions in atherosclerosis, but its role in coronary artery disease (CAD) is unclear. Here, we studied the genetic role of IL-13 in CAD in a Chinese Han population using tag SNPs covering the whole IL13 gene (i.e., rs1881457, rs2069744 and rs20541) and a two-stage cohort containing 1863 CAD cases and 1841 controls. Traditional risk factors for CAD, such as age, BMI, and other factors, were used as covariates in logistic regression analysis. In the total population, we found that two haplotypes of IL13 (ATG and ATA, ordered rs1881457C-rs2069744T-rs20541A) significantly contributed to the risk of CAD with adjusted p values less than 0.05 (padj = 0.019 and padj = 0.042, respectively). In subgroup population analyses, the variant rs1881457C was found to significantly contribute to a nearly two fold increase in the risk of CAD in men (padj = 0.023, OR = 1.91, 95% CI: 1.09-3.33). The variant rs1881457C also significantly contributed to a nearly twofold risk of late-onset CAD (padj = 0.024, OR = 1.93, 95% CI: 1.09-3.42). In conclusion, IL13 might be involved in CAD via different mechanisms under different conditions in the Chinese Han population. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|