Immunolocalization of c-Fos and c-Jun in Rat Ocular Surface Epithelium
| Autor: | Shizuya Saika, Yoshitaka Ohnishi, Kumi Shirai, Akira Ooshima, Osamu Yamanaka, Yuka Okada, Yoshiji Kawashima |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Male
Pathology medicine.medical_specialty Conjunctiva Proto-Oncogene Proteins c-jun Limbus Corneae c-Fos Immunoenzyme Techniques Cellular and Molecular Neuroscience Cornea medicine Animals Rats Wistar Corneal epithelium biology c-jun Epithelium Corneal Epithelial Cells General Medicine Molecular biology eye diseases Sensory Systems Epithelium Rats Ophthalmology AP-1 transcription factor medicine.anatomical_structure Cytoplasm biology.protein Female sense organs Proto-Oncogene Proteins c-fos |
| Zdroj: | Ophthalmic Research. 32:9-12 |
| ISSN: | 1423-0259 0030-3747 |
| DOI: | 10.1159/000055580 |
| Popis: | We immunohistochemically located c-Fos and c-Jun, the major components of transcription factor activator protein 1 (AP1), in normal epithelia of rat cornea and conjunctiva to determine the expression of these genes in the ocular surface epithelia. Immunoreactivity for c-Fos was detected in the nuclei of basal cells of the limbal and conjunctival epithelia, while that for c-Jun was detected in the cytoplasm of the cells of these epithelia. The corneal epithelium lacked immunoreactivity for either protein. AP1 may have an important role in the maintenance of homeostasis of limbal and conjunctival epithelia. |
| Databáze: | OpenAIRE |
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