Increasing pH Causes Faster Anion- and Cation-Transport Rates through a Synthetic Ion Channel
| Autor: | Nandita Madhavan, Mary S. Gin |
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| Rok vydání: | 2007 |
| Předmět: |
Anions
Cyclodextrins Ion Transport Static Electricity Organic Chemistry Inorganic chemistry Hydrogen-Ion Concentration Electrostatics Biochemistry Ion Channels Ion Quaternary Ammonium Compounds Nanopore chemistry.chemical_compound Membrane chemistry Cations Molecular Medicine Ammonium Molecular Biology Phospholipids Cation transport Ion transporter Ion channel |
| Zdroj: | ChemBioChem. 8:1834-1840 |
| ISSN: | 1439-7633 1439-4227 |
| DOI: | 10.1002/cbic.200700321 |
| Popis: | Ion-channel mimics are able to transmit electrical signals across phospholipid membranes, and can be envisioned as nanoswitches for molecular electronics. Here, we reported the use of pH to alter ion-transport rates through a synthetic aminocyclodextrin ion channel. Both cation- and anion-transport rates were found to increase with an increase in pH due to the unique electrostatics of the multiple ammonium groups that line the channel pore. Such pH regulation of ion transport rates is unique and can be exploited for sensing applications. |
| Databáze: | OpenAIRE |
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