MRI-based tumor inter-fraction motion statistics for rectal cancer boost radiotherapy
| Autor: | Mark De Ridder, Bram van Asselen, Onne Reerink, Marielle E.P. Philippens, Robbe Van den Begin, Jan J W Lagendijk, Bas W. Raaymakers, Jean Paul J.E. Kleijnen, J.P.M. Burbach, Martijn Intven |
|---|---|
| Přispěvatelé: | Faculty of Medicine and Pharmacy, Clinical sciences, Radiation Therapy, Translational Radiation Oncology and Physics |
| Rok vydání: | 2018 |
| Předmět: |
Male
Time Factors Colorectal cancer medicine.medical_treatment Radiotherapy Planning Datasets as Topic Radiotherapy Image-Guided/methods Radiotherapy Setup Errors Magnetic Resonance Imaging/methods 030218 nuclear medicine & medical imaging 0302 clinical medicine Computer-Assisted/methods Dose escalation Dose Fractionation Adjuvant Medicine(all) Radiation Follow up studies Hematology General Medicine Middle Aged Magnetic Resonance Imaging Tumor Burden Gross tumor volume Datasets as Topic/statistics & numerical data Oncology Rectal Neoplasms/epidemiology 030220 oncology & carcinogenesis Female Radiology Adult medicine.medical_specialty Motion 03 medical and health sciences Journal Article medicine Humans Radiology Nuclear Medicine and imaging In patient Tumor Burden/physiology Radiotherapy Planning Computer-Assisted/methods Aged Radiotherapy Rectal Neoplasms business.industry Image-Guided/methods Radiotherapy Planning Computer-Assisted Dose fractionation medicine.disease Radiation therapy Radiotherapy Adjuvant Dose Fractionation Radiation business Radiotherapy Image-Guided Follow-Up Studies Radiotherapy Setup Errors/statistics & numerical data |
| Zdroj: | Acta Oncologica, 58(2), 232. Informa Healthcare |
| ISSN: | 1651-226X 0284-186X |
| Popis: | Background: In patients diagnosed with rectal cancer, dose escalation is currently being investigated in a large number of studies. Since there is little known on gross tumor volume (GTV) inter-fraction motion for rectal cancer, a wide variety in margins is used. Purpose of this study is to quantify GTV inter-fraction motion statistics on different timescales and to give estimates of planning target volume (PTV) margins. Material and methods: Thirty-two patients, diagnosed with rectal cancer, were included. To investigate motion from week-to-week, 16 patients underwent a pretreatment and five weekly MRIs, prior to a radiotherapy (RT) fraction of the chemoradiotherapy treatment. To investigate motion from day-to-day, the remaining 16 patients underwent five daily MRIs before each fraction in one week of RT. GTV was delineated on all scans according to guidelines. Scans were aligned on bony anatomy with the first MRI. For both datasets separately, GTV inter-fraction motion was determined based on center-of-gravity displacement. Therefrom, systematic and random errors were determined in left/right (LR), anterior/posterior and cranial/caudal (CC) direction. PTV margin estimates were calculated and evaluated on GTV coverage. Results: Systematic and random errors were found in the range of 2.3–4.8 mm and 1.5–3.3 mm from week-to-week, and 1.8–4.5 mm and 1.8–4.0 mm from day-to-day, respectively. On both timescales, similar motion patterns were found; the most motion was observed in CC whilst the least motion was observed in LR. On the week-to-week data more systematic and less random motion was observed compared to the day-to-day data. Overall, only slight differences in margin estimates were found. Derived PTV margin estimates were found to give adequate GTV coverage. Conclusion: GTV inter-fraction motion, on a week-to-week and day-to-day timescale, can be accounted for using motion statistics presented in this study. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|