The biomimetic extracellular matrix: a therapeutic tool for breast cancer research

Autor: Juan A. Marchal, Gema Jiménez, Marta Tamayo-Angorrilla, Julia López de Andrés
Rok vydání: 2021
Předmět:
Zdroj: Translational research : the journal of laboratory and clinical medicine. 247
ISSN: 1878-1810
Popis: Background: A deeper knowledge of the functional versatility and dynamic nature of the ECM has improved the understanding of cancer biology. Translational Significance: This work provides an in-depth view of the importance of the ECM to develop more mimetic breast cancer models, which aim to recreate the components and architecture of tumor microenvironment. Special focus is placed on decellularized matrices derived from tissue and cell culture, both in procurement and applications, as they have achieved great success in cancer research and pharmaceutical sector. The extracellular matrix (ECM) is increasingly recognized as a master regulator of cell behavior and response to breast cancer (BC) treatment. During BC progression, the mammary gland ECM is remodeled and altered in the composition and organization. Accumulated evidence suggests that changes in the composition and mechanics of ECM, orchestrated by tumor-stromal interactions along with ECM remodeling enzymes, are actively involved in BC progression and metastasis. Understanding how specific ECM components modulate the tumorigenic process has led to an increased interest in the development of biomaterial-based biomimetic ECM models to recapitulate key tumor characteristics. The decellularized ECMs (dECMs) have emerged as a promising in vitro 3D tumor model, whose recent advances in the processing and application could become the biomaterial by excellence for BC research and the pharmaceutical industry. This review offers a detailed view of the contribution of ECM in BC progression, and highlights the application of dECM-based biomaterials as promising personalized tumor models that more accurately mimic the tumorigenic mechanisms of BC and the response to treatment. This will allow the design of targeted therapeutic approaches adapted to the specific characteristics of each tumor that will have a great impact on the precision medicine applied to BC patients. (Translational Research 2022; 247:117 136)
Junta de Andalucia PIN-0224-2019
Convocatoria de Proyectos Intramurales ibs.GRANADA INTRAIBS-2020-10
Spanish Government RTI2018-101309-B-C22
Junta de Andalucia P18-FR-2470 SOMM17/6109/UGR
Ministry of Economy and Competitiveness, Instituto de Salud Carlos III PIE16/00045 DTS19/00143 DTS17/00087
Chair "Doctors GaleraRequena in cancer stem cell research" CMC-CTS963 Universidad de Granada/CBUA
Databáze: OpenAIRE
Externí odkaz: