Synthesis of 3-hydroxy-5-alkoxyhomophthalates by domino ‘2 : 1-coupling/intramolecular aldol condensation’ reactions of 1,3-bis(trimethylsilyloxy)-1,3-butadienes with tetraalkoxymethanes

Autor:	Mathias Lubbe, Peter Langer
Rok vydání:	2010
Předmět:	Aldehydes Organic Chemistry Condensation chemistry.chemical_element Stereoisomerism Biochemistry Medicinal chemistry Catalysis Domino chemistry Aldol reaction Intramolecular force Butadienes Organic chemistry Aldol condensation Physical and Theoretical Chemistry Methane Palladium
Zdroj:	Org. Biomol. Chem.. 8:881-885
ISSN:	1477-0539 1477-0520
DOI:	10.1039/b918466j
Popis:	The first domino '2 : 1 condensation/intramolecular aldol' reactions of 1,3-bis(trimethylsilyloxy)-1,3-butadiene with tetraalkoxymethanes provide a convenient approach to 3-hydroxy-5-alkoxyhomophthalates. These products, which contain one free and one protected hydroxyl group, can be functionalized by palladium(0)-catalyzed cross-coupling reactions.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26510c5385dd5858ca9483c8a4c99bf5 https://doi.org/10.1039/b918466j Zobrazit plný text záznamu