The effect of iron overload in the hearts of patients with beta-thalassemia
| Autor: | Tzonou Ai, Stella Brili, Aggeli Cj, C. Pitsavos, P.K. Toutouzas, Costas Tentolouris, Castelanos Ss |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Adult
medicine.medical_specialty Iron Overload Clinical Investigations Hemodynamics Atrial natriuretic peptide Internal medicine Humans Medicine Heart Atria cardiovascular diseases Analysis of Variance Univariate analysis biology business.industry beta-Thalassemia Models Cardiovascular Case-control study Beta thalassemia Heart General Medicine medicine.disease Ferritin Endocrinology Echocardiography Case-Control Studies Ferritins Circulatory system cardiovascular system biology.protein Regression Analysis Cardiology and Cardiovascular Medicine business Isovolumic relaxation time Atrial Natriuretic Factor |
| Zdroj: | Clinical Cardiology. 20:541-546 |
| ISSN: | 1932-8737 0160-9289 |
| DOI: | 10.1002/clc.4960200607 |
| Popis: | BACKGROUND AND HYPOTHESIS An important complication of beta-thalassemia is iron deposition in cardiac tissues resulting in fibrosis and dysfunction. Our aim was the investigation of the possible clinical effect of iron loading in the heart of patients with beta-thalassemia prior to the appearance of symptoms of depressed systolic function. METHODS Thirty-five patients with beta-thalassemia, of whom 24 had the major type (Group 1) and 11 had the intermedia type (Group 2) were studied. Eleven age- and gender-matched controls were also studied (Group 3). All patients were evaluated echocardiographically and were shown to have normal left ventricular systolic function and dimensions. Serum ferritin, atrial natriuretic peptide (ANP), left atrial diameter (LAD), peak early mitral inflow velocity (E), peak late mitral inflow velocity (A), E/A ratio, deceleration time of the mitral inflow E wave (DT), and isovolumic relaxation time (IVRT) were measured. RESULTS Univariate analysis showed that both groups of patients had similarly increased LAD and ANP plasma levels. Group 1 had a higher E/A ratio (2.27 +/- 0.88) SS than Group 2 (1.69 +/- 0.47, p = 0.05) and Group 3 (1.50 +/- 0.38, p = 0.01). Serum ferritin was significantly higher in Group 1 (3.526 +/- 0.352) than in Group 2 (2.808 +/- 0.288, p < 10(-5) and Group 3 (2.139 +/- 0.124, p < 10(-5). Multivariate analysis showed that ANP is a factor that is affected by the LAD and E/A ratio and that serum ferritin levels affect the LAD and E/A ratio. CONCLUSIONS Although LAD and ANP levels are increased in patients with beta-thalassemia, the increased serum ferritin levels of patients seem to affect left atrial size and E/A ratio. ANP secretion is consecutively affected by these factors. |
| Databáze: | OpenAIRE |
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