Regeneration of Human Infarcted Heart Muscle by Intracoronary Autologous Bone Marrow Cell Transplantation in Chronic Coronary Artery Disease
| Autor: | Michael A. Brehm, C. Antke, Rüdiger V. Sorg, Thomas Bartsch, Bodo E. Strauer, Matthias Köstering, Peter Wernet, Gesine Kögler, Tobias Zeus, Hans-Wilhelm Müller, C.M. Schannwell |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
Male medicine.medical_specialty Myocardial Infarction Coronary Artery Disease Coronary artery disease Internal medicine medicine Humans Regeneration cardiovascular diseases Myocardial infarction Bone Marrow Transplantation business.industry Regeneration (biology) Myocardium Heart Middle Aged medicine.disease Autologous bone Coronary Vessels Cardiovascular physiology Transplantation Circulatory system Infarcted heart Chronic Disease cardiovascular system Cardiology business Cardiology and Cardiovascular Medicine |
| Zdroj: | Journal of the American College of Cardiology. 46(9):1651-1658 |
| ISSN: | 0735-1097 |
| DOI: | 10.1016/j.jacc.2005.01.069 |
| Popis: | ObjectivesStem cell therapy may be useful in chronic myocardial infarction (MI); this is conceivable, but not yet demonstrated in humans.BackgroundAfter acute MI, bone marrow-derived cells improve cardiac function.MethodsWe treated 18 consecutive patients with chronic MI (5 months to 8.5 years old) by the intracoronary transplantation of autologous bone marrow mononuclear cells and compared them with a representative control group without cell therapy.ResultsAfter three months, in the transplantation group, infarct size was reduced by 30% and global left ventricular ejection fraction (+15%) and infarction wall movement velocity (+57%) increased significantly, whereas in the control group no significant changes were observed in infarct size, left ventricular ejection fraction, or wall movement velocity of infarcted area. Percutaneous transluminal coronary angioplasty alone had no effect on left ventricular function. After bone marrow cell transplantation, there was an improvement of maximum oxygen uptake (Vo2max, +11%) and of regional 18F-fluor-desoxy-glucose uptake into infarct tissue (+15%).ConclusionsThese results demonstrate that functional and metabolic regeneration of infarcted and chronically avital tissue can be realized in humans by bone marrow mononuclear cell transplantation. |
| Databáze: | OpenAIRE |
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