Paradoxical effect of sibutramine on autonomic cardiovascular regulation in obese hypertensive patients
| Autor: | Tobias Pischon, Christoph Schroeder, Jens Jordan, Friedrich C. Luft, Andreas L. Birkenfeld, Jens Tank, Arya M. Sharma |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
Male Sympathetic nervous system Supine position Adolescent Valsalva Maneuver Posture Blood Pressure Autonomic Nervous System Placebo Body Mass Index Double-Blind Method Heart Rate Diabetes mellitus Appetite Depressants Autonomic reflex Humans Medicine Single-Blind Method Obesity Aged Waist-Hip Ratio Endocrine and Autonomic Systems business.industry Hemodynamics Cold pressor test Arrhythmias Cardiac Baroreflex Middle Aged medicine.disease Blood pressure medicine.anatomical_structure Anesthesia Hypertension Female Neurology (clinical) business Cyclobutanes Sibutramine medicine.drug |
| Zdroj: | Clinical Autonomic Research. 15:200-206 |
| ISSN: | 1619-1560 0959-9851 |
| Popis: | Sibutramine, a serotonin and norepinephrine transporter blocker, is a common adjunctive obesity treatment. Acute studies in healthy subjects suggested that an inhibitory central nervous mechanism might attenuate the peripheral stimulatory effect on the sympathetic nervous system. This notion has not been tested in overweight and obese patients.We conducted a randomized, controlled clinical study in hypertensive patients with BMIor = 27 to40 kg/m(2). After 4 week placebo run-in period patients were randomized to four different antihypertensive treatments or placebo. After 4 weeks of antihypertensive therapy, patients were additionally treated with sibutramine 15 mg o. d. for 3 months. Patients underwent cardiovascular autonomic reflex testing and a graded head-up tilt test at the end of each phase.Mean body weight decreased from 98.5+/-4 to 94.7+/-4 kg (p0.05) between end of placebo run-in and end of sibutramine treatment. Supine blood pressure was 154+/-3/80+/-2, 145+/-3/76+/-2 and 150+/-3/79+/-2mmHg at the end of placebo run-in, after antihypertensive titration (ns) and end of sibutramine treatment (ns), respectively. Blood pressure was affected similarly during head up tilt testing. The systolic blood pressure response to cold pressor testing was diminished with sibutramine (p0.01). Sibutramine decreased low frequency systolic blood pressure oscillations in the supine position (p0.01).Resting blood pressure tends to increase with sibutramine, whereas blood pressure during sympathetic stimulation and low frequency blood pressure oscillations are decreased. These paradoxical changes are consistent with previous studies in healthy subjects and suggest a combination of peripheral and central nervous system mechanisms. |
| Databáze: | OpenAIRE |
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