Supplementary Figures 1-7 from Comprehensive Transcriptome and Mutational Profiling of Endemic Burkitt Lymphoma Reveals EBV Type–Specific Differences

Autor: Jeffrey A. Bailey, Ann M. Moormann, John Michael Ong'echa, Juliana A. Otieno, Hongbo Yu, Cliff I. Oduor, Yasin Kaymaz
Rok vydání: 2023
Popis: S1. Assessment of putative tumor purity levels using IRIS signature genes from Abbas et al. S2. Epstein-barr virus transcription and lytic activity level measurements within primary eBL biopsies. S3. Dimension reduction with principal component analysis (PCA) on gene expression profiles. S4. All expressed human gene expression comparison between eBL tumors carrying EBV type 1 and eBL tumors with type 2 in log2 scale. S5. Sample to sample correlation heatmap of eBL, sBL tumors, and long-term BL cultures after removing all unwanted covariates except tumor origins. Gene expression profiles group into two clusters based on endemic and sporadic origins. S6. A) Common SNP counts detected in each sample after variant calling with RNAseq data by subsampling to balance the detection power (dbSNP v146). B) Rare non-synonymous variant fractions detected in each sample. S7. Lollipop plot for the non-synonymous mutations detected in BL tumors.
Databáze: OpenAIRE