Impulse control under emotion processing: an fMRI investigation in borderline personality disorder compared to non-patients and cluster-C personality disorder patients

Autor: Arnoud Arntz, Gregor Domes, Oliver Tüscher, Bastian Willenborg, Nicolette Siep, Gitta A. Jacob, Rainer Goebel, Andreas Sprenger, Linda van Zutphen
Přispěvatelé: Netherlands Institute for Neuroscience (NIN), Klinische Psychologie (Psychologie, FMG), RS: FPN CPS III, Section Clinical Psychology, Clinical Psychological Science, Vision, RS: FPN CN 1, Section Experimental Health Psychology
Rok vydání: 2019
Předmět:
Brain activity and meditation
Emotions
ATTENTIONAL BIAS
Audiology
Behavioral Neuroscience
0302 clinical medicine
Borderline Personality Disorder
BRAIN
Borderline personality disorder
Original Research
media_common
Neuropsychology
WOMEN
BPD
Frontal eye fields
Magnetic Resonance Imaging
Psychiatry and Mental health
Neurology
Response inhibition
RELIABILITY
medicine.symptom
Psychology
RESPONSE-INHIBITION
Adult
SEVERITY INDEX
Impulsivity
medicine.medical_specialty
FEMALE-PATIENTS
Cognitive Neuroscience
media_common.quotation_subject
Neuroimaging
Stimulus (physiology)
Personality Disorders
behavioral disciplines and activities
03 medical and health sciences
Cellular and Molecular Neuroscience
mental disorders
medicine
Humans
Personality
Radiology
Nuclear Medicine and imaging
PSYCHOMETRIC EVALUATION
METAANALYSIS
Emotion
Inferior parietal lobule
medicine.disease
030227 psychiatry
Disruptive
Impulse Control
and Conduct Disorders
Neurology (clinical)
COMORBIDITY
030217 neurology & neurosurgery
Zdroj: Brain Imaging and Behavior, 14, 2107-2121. Springer New York
Brain imaging and behavior, 14(6), 2107-2121. Springer New York
Brain Imaging and Behavior, 14(6). Springer, Cham
Brain Imaging and Behavior
ISSN: 1931-7565
1931-7557
DOI: 10.1007/s11682-019-00161-0
Popis: Impulsivity is a characteristic syndromal and neurobehavioral feature of borderline personality disorder (BPD). Research suggests an important interaction between high negative emotions and low behavioral inhibition in BPD. However, knowledge about the generalizability across stimulus categories and diagnosis specificity is limited. We investigated neural correlates of hypothesized impaired response inhibition of BPD patients to negative, positive and erotic stimuli, by comparing them to non-patients and cluster-C personality disorder patients. During fMRI scanning, 53 BPD patients, 34 non-patients and 20 cluster-C personality disorder patients completed an affective go/no-go task, including social pictures. BPD patients showed more omission errors than non-patients, independent of the stimulus category. Furthermore, BPD patients showed higher activity in the inferior parietal lobule and frontal eye fields when inhibiting negative versus neutral stimuli. Activity of the inferior parietal lobule correlated positively with the BPD checklist subscale impulsivity. When inhibiting emotional stimuli, BPD patients showed an altered brain activity in the inferior parietal lobe and frontal eye fields, whereas previously shown dysfunctional prefrontal activity was not replicated. BPD patients showed a general responsivity across stimulus categories in the frontal eye fields, whereas effects in the inferior parietal lobe were specific for negative stimuli. Results of diagnosis specificity support a dimensional rather than a categorical differentiation between BPD and cluster-C patients during inhibition of social emotional stimuli. Supported by behavioral results, BPD patients showed no deficiencies in emotionally modulated response inhibition per se but the present findings rather hint at attentional difficulties for emotional information. Electronic supplementary material The online version of this article (10.1007/s11682-019-00161-0) contains supplementary material, which is available to authorized users.
Databáze: OpenAIRE
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