The impact of postoperative complications and delay of adjuvant chemotherapy on oncological outcomes in patients with colorectal cancer
| Autor: | Ismail Gögenur, Tina Fransgaard, Lau Caspar Thygesen |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Multivariate analysis Colorectal cancer medicine.medical_treatment colorectal cancer Disease-Free Survival 03 medical and health sciences Postoperative Complications 0302 clinical medicine Internal medicine Epidemiology of cancer medicine postoperative complications Humans Chemotherapy Proportional hazards model business.industry Hazard ratio Gastroenterology Odds ratio Prognosis medicine.disease Chemotherapy Adjuvant 030220 oncology & carcinogenesis 030211 gastroenterology & hepatology Observational study Colorectal Neoplasms business cancer epidemiology |
| Zdroj: | Fransgaard, T, Caspar Thygesen, L & Gögenur, I 2021, ' The impact of postoperative complications and delay of adjuvant chemotherapy on oncological outcomes in patients with colorectal cancer ', Colorectal Disease, vol. 23, no. 5, pp. 1132-1140 . https://doi.org/10.1111/codi.15538 |
| Popis: | Aim: Postoperative complications are believed to result in poorer long-term oncological outcomes. The contribution of time to chemotherapy has not been analysed in detail. Our aim was to examine the association between postoperative complications and long-term oncological outcomes and overall survival, and the influence of delay in chemotherapy on these outcomes. Method: The study was a nationwide register-based observational study that included patients undergoing surgery for colorectal cancer and receiving adjuvant chemotherapy in Denmark between 2010 and 2015. Information regarding postoperative complications was obtained from the Danish Colorectal Cancer Group national clinical registry. A Cox regression model was used to estimate disease-free survival, recurrence-free survival and all-cause mortality in patients surviving for 180 days or more after surgery. Results: A total of 4083 patients were included, of whom 690 had postoperative complications. Postoperative complications were associated with increased odds of delay to adjuvant chemotherapy (odds ratio 4.56, 95% CI 3.67–5.66, p |
| Databáze: | OpenAIRE |
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