Depression in dementia with Lewy bodies: A comparison with Alzheimer's disease

Autor: Chein-Wei Wang, Te-Jen Lai, Pai-Yi Chiu, Shin-Hua Li, Chih-Li Lin, Chun-Tang Tsai
Rok vydání: 2017
Předmět:
Male
Anhedonia
Dementia with Lewy bodies
lcsh:Medicine
Social Sciences
Disease
Geriatric Depression
0302 clinical medicine
Medicine and Health Sciences
Psychology
lcsh:Science
Depression (differential diagnoses)
Aged
80 and over
Movement Disorders
Multidisciplinary
Depression
Cognitive Neurology
Drugs
Neurodegenerative Diseases
Parkinson Disease
Antidepressants
Middle Aged
Neurology
Female
Alzheimer's disease
medicine.symptom
Research Article
Lewy Body Disease
medicine.medical_specialty
Cognitive Neuroscience
Geriatric Psychiatry
Taiwan
behavioral disciplines and activities
03 medical and health sciences
Alzheimer Disease
Neuropsychology
Rating scale
Mental Health and Psychiatry
mental disorders
medicine
Humans
Dementia
Psychiatry
Aged
Neuropsychological Testing
Pharmacology
030214 geriatrics
Mood Disorders
business.industry
lcsh:R
Biology and Life Sciences
Odds ratio
medicine.disease
nervous system diseases
nervous system
Geriatrics
Cognitive Science
lcsh:Q
business
030217 neurology & neurosurgery
Neuroscience
Zdroj: PLoS ONE
PLoS ONE, Vol 12, Iss 6, p e0179399 (2017)
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0179399
Popis: Background Depression is highly associated with dementia, and this study will compare the frequencies, severity, and symptoms of depression between dementia with Lewy bodies (DLB) and Alzheimer’s disease (AD). Methods Frequency of depression was determined according to the DSM-IV criteria for major depression or the National Institute of Mental Health criteria for depression in AD (NIMH-dAD). Severity of depression were assessed using the Hamilton Depression Rating Scale, the Cornell Scale for Depression in Dementia, and the depression subscale in Neuropsychiatric Inventory. The rates of depressive symptoms were compared between AD and DLB. Results A total of 312 patients were investigated (AD/DLB = 241/71). The frequency of major depression was significantly higher (p = 0.017) in DLB (19.7%) than in AD (8.7%). The higher frequency of depression in DLB was not reproduced by using the NIMH-dAD criteria (DLB: AD = 43.7%: 33.2%; p = 0.105). The severity of depression was higher in DLB than in AD according to the Hamilton Depression Rating Scale (p < 0.001) and the Cornell Scale for Depression in Dementia (p < 0.001). Among depressive symptoms, pervasive anhedonia had the highest odds ratio in DLB compared with AD. Conclusion This is the first study using the NIMH-dAD criteria to investigate the frequency of depression in DLB. Our study shows that co-morbid major depression is more frequent in DLB than in AD. Pervasive anhedonia had the greatest value for the differential diagnosis of depression between DLB and AD.
Databáze: OpenAIRE
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