Early blood pressure alterations are associated with pro-inflammatory markers in type 1 diabetes mellitus
| Autor: | Francisco Manuel Visiedo-Garcia, F Carral-San Laureano, Francisco Javier Vilchez-Lopez, Isabel Mateo-Gavira, Manuel Aguilar-Diosdado, Maria Victoria Garcia-Palacios |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Inflammation Male Type 1 diabetes endocrine system diseases business.industry nutritional and metabolic diseases 030209 endocrinology & metabolism 030204 cardiovascular system & hematology medicine.disease Young Adult 03 medical and health sciences Cross-Sectional Studies Diabetes Mellitus Type 1 0302 clinical medicine Blood pressure Masked Hypertension Multivariate Analysis Immunology Internal Medicine medicine Humans Female business Biomarkers |
| Zdroj: | Journal of Human Hypertension. 31:151-156 |
| ISSN: | 1476-5527 0950-9240 |
| DOI: | 10.1038/jhh.2016.56 |
| Popis: | The aim of this study was to evaluate the relationship between early blood pressure (BP) changes (detected using ambulatory BP monitoring; ABPM) with different markers of inflammation and endothelial dysfunction in patients with type 1 diabetes mellitus (T1DM). The study design was observational cross-sectional in 85 T1DM patients, clinically normotensive and with normo-albuminuria. We analyzed the relationships between ABPM-measured BP alterations over 24 h with the inflammatory cytokines (interleukin-6 (IL-6), tumor necrosis factor-α and vascular endothelial growth factor (VEGF)) and the markers of endothelial damage (vascular adhesion molecule, intercellular adhesion molecule and plasminogen activator inhibitor-1 (PAI)). Despite being recorded as normotensive, 27 (31.8%) subjects presented with an average of pathological BP. VEGF levels were significantly elevated in the patients with an altered mean diurnal values compared with normotensives (112.33 (72.87-213.53) pg ml |
| Databáze: | OpenAIRE |
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