Immunoglobulin A (IgA) with properties of both cryoglobulin and pyroglobulin
| Autor: | Akiko Watanabe, Motoshi Kitamura, Masaru Shimizu |
|---|---|
| Rok vydání: | 1974 |
| Předmět: |
Electrophoresis
Male Immunoglobulin A Immunodiffusion Hot Temperature Clinical Biochemistry macromolecular substances Immunoglobulin light chain Biochemistry Cryoglobulin medicine Humans Cellulose Immunoelectrophoresis Immunoglobulin Fragments Cryoglobulins Multiple myeloma biology Viscosity Chemistry Biochemistry (medical) Disulfide bond General Medicine Middle Aged medicine.disease J chain Pyroglobulin Agar Chromatography Gel biology.protein Multiple Myeloma Oxidation-Reduction Ultracentrifugation |
| Zdroj: | Clinica Chimica Acta. 52:231-237 |
| ISSN: | 0009-8981 |
| DOI: | 10.1016/0009-8981(74)90215-0 |
| Popis: | Cryo- and pyroprecipitability of protein in the serum of a patient with multiple myeloma were both derived from the same polymerized IgA with lambda light chain, and were composed mainly of 16.1 S which migrated to the β2 region. A 6.7S component produced by reduction of the polymerized IgA did not reveal these properties. This suggests an important role of disulfide bonds in the conformation of IgA polymers with these thermoprecipitabilities. |
| Databáze: | OpenAIRE |
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