Association of ADIPOQ-rs2241766 and FTO-rs9939609 genetic variants with body mass index trajectory in women of reproductive age over 6 years of follow-up: the PREDI study
| Autor: | Marco Fabio Mastroeni, Caroline Kroll, Gilberto Kac, Dayana Rodrigues Farias, Thaís Rangel Bousquet Carrilho |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
0301 basic medicine Genotype Alpha-Ketoglutarate-Dependent Dioxygenase FTO Medicine (miscellaneous) 030209 endocrinology & metabolism Overweight Polymorphism Single Nucleotide Body Mass Index 03 medical and health sciences symbols.namesake 0302 clinical medicine Pregnancy Humans Medicine Genetic Predisposition to Disease Obesity Prospective Studies Poisson regression Prospective cohort study Genotyping 030109 nutrition & dietetics Nutrition and Dietetics business.industry Confounding nutritional and metabolic diseases medicine.disease symbols Female Adiponectin medicine.symptom business Body mass index Demography |
| Zdroj: | European Journal of Clinical Nutrition. 76:159-172 |
| ISSN: | 1476-5640 0954-3007 |
| DOI: | 10.1038/s41430-021-00911-8 |
| Popis: | Interindividual variations in body mass index (BMI) can be partially explained by genetic differences. We aimed to examine the association of the ADIPOQ-rs2241766, LEP-rs7799039 and FTO-rs9939609 genetic variants with BMI trajectory in women of reproductive age over 6 years of follow-up. This was a prospective study that used data from 435 women of the PREDI Study conducted in Brazil. Socioeconomic, biological and anthropometric data were collected at four time points: 2012 (baseline) in the maternity hospital, and 2013–14, 2016–17 and 2018 (1st, 2nd and 3rd follow-ups) at the participant’s home. Genotyping was performed by PCR-RFLP. Linear mixed-effect and Poisson regression models were used to address the association of ADIPOQ, LEP and FTO genotypes with BMI and overweight/obesity status. Women carrying the risk allele (TA or AA) of the FTO-rs9939609 genetic variant had a 1.16 kg/m2 higher BMI over the follow-up period than those carrying the wild-type genotype (TT), even when adjusted for potential confounders (95% CI: 0.23–2.10, p = 0.015). The risk of obesity associated with the FTO-TA or AA genotype decreased over the years, demonstrating an influence of time on its trajectory (IRR = 0.99, 95% CI: 0.98–0.99, p = 0.016). There was no variation in BMI trajectories for the ADIPOQ-rs2241766, LEP-rs7799039 or FTO-rs9939609 genetic variant. The results of this study suggest that monitoring women of reproductive age with ADIPOQ-rs2241766 TG/GG or FTO-rs9939609 TA/AA genotypes may be an important strategy to reduce maternal excess body weight and, consequently, the long-term public health burden of obesity. |
| Databáze: | OpenAIRE |
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