Antiepileptic Effects of MK-801, a Noncompetitive NMDA-Receptor Antagonist, in the Low-Frequency Kindling Model of Epilepsy
| Autor: | Ryoko Shibata, Kenji Emori, Masayoshi Kurachi, Yoshio Minabe |
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| Rok vydání: | 1992 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Hippocampus Receptors N-Methyl-D-Aspartate Epilepsy Internal medicine Kindling Neurologic medicine Animals Rats Wistar Evoked Potentials Seizure threshold business.industry Kindling General Neuroscience Antagonist Electroencephalography Long-term potentiation General Medicine medicine.disease Rats Psychiatry and Mental health Endocrinology Anticonvulsant Neurology NMDA receptor Anticonvulsants Neurology (clinical) Dizocilpine Maleate Kindling model business |
| Zdroj: | Psychiatry and Clinical Neurosciences. 46:755-761 |
| ISSN: | 1440-1819 1323-1316 |
| DOI: | 10.1111/j.1440-1819.1992.tb00552.x |
| Popis: | We assessed the acute effect of MK-801 (0.05-0.7 mg/kg), a noncompetitive NMDA-receptor antagonist, on hippocampus-kindled seizures induced with low-frequency (2 Hz) electrical stimulations. MK-801 dose-dependently increased the seizure threshold (PNT, the number of stimulating pulses required for the triggering of epileptic after discharge), whereas most of the previous studies which assessed the effect of MK-801 on kindled seizures could not detect the elevation of seizure threshold by MK-801. In addition MK-801 decreased the severity of induced seizures at low doses at which previous studies could not detect the antiepileptic effect of MK-801, suggesting that the low-frequency kindling technique might be a more sensitive and reliable model of epilepsy than the conventional high-frequency kindling technique. |
| Databáze: | OpenAIRE |
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