A/C magnetic hyperthermia of melanoma mediated by iron(0)/iron oxide core/shell magnetic nanoparticles: a mouse study
| Autor: | Marla Pyle, Xiaoxuan Leaym, Olga Koper, Franklin Orban Kroh, Hongwang Wang, Raj Kumar Dani, Raja Shekar Rachakatla, Viktor Chikan, Brandon Walker, Sivasai Balivada, Deryl L. Troyer, Thilani N. Samarakoon, Stefan H. Bossmann, Masaaki Tamura |
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| Jazyk: | angličtina |
| Předmět: |
Pathology
medicine.medical_specialty Cancer Research Porphyrins medicine.medical_treatment Iron Magnetic Field Therapy Iron oxide Melanoma Experimental Metal Nanoparticles Photodynamic therapy Apoptosis 02 engineering and technology 010402 general chemistry 01 natural sciences lcsh:RC254-282 chemistry.chemical_compound Mice Genetics Medicine Animals business.industry Melanoma Cancer Hyperthermia Induced 021001 nanoscience & nanotechnology medicine.disease lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens Ferrosoferric Oxide 0104 chemical sciences 3. Good health Ferumoxytol Mice Inbred C57BL Magnetic hyperthermia chemistry Oncology Cancer research Magnetic nanoparticles Female 0210 nano-technology business Research Article |
| Zdroj: | BMC Cancer, Vol 10, Iss 1, p 119 (2010) BMC Cancer |
| ISSN: | 1471-2407 |
| DOI: | 10.1186/1471-2407-10-119 |
| Popis: | Background There is renewed interest in magnetic hyperthermia as a treatment modality for cancer, especially when it is combined with other more traditional therapeutic approaches, such as the co-delivery of anticancer drugs or photodynamic therapy. Methods The influence of bimagnetic nanoparticles (MNPs) combined with short external alternating magnetic field (AMF) exposure on the growth of subcutaneous mouse melanomas (B16-F10) was evaluated. Bimagnetic Fe/Fe3O4 core/shell nanoparticles were designed for cancer targeting after intratumoral or intravenous administration. Their inorganic center was protected against rapid biocorrosion by organic dopamine-oligoethylene glycol ligands. TCPP (4-tetracarboxyphenyl porphyrin) units were attached to the dopamine-oligoethylene glycol ligands. Results The magnetic hyperthermia results obtained after intratumoral injection indicated that micromolar concentrations of iron given within the modified core-shell Fe/Fe3O4 nanoparticles caused a significant anti-tumor effect on murine B16-F10 melanoma with three short 10-minute AMF exposures. We also observed a decrease in tumor size after intravenous administration of the MNPs followed by three consecutive days of AMF exposure 24 hrs after the MNPs injection. Conclusions These results indicate that intratumoral administration of surface modified MNPs can attenuate mouse melanoma after AMF exposure. Moreover, we have found that after intravenous administration of micromolar concentrations, these MNPs are capable of causing an anti-tumor effect in a mouse melanoma model after only a short AMF exposure time. This is a clear improvement to state of the art. |
| Databáze: | OpenAIRE |
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