Values of Alpha 1 Microglobulin Does Not Differ between Individuals with and without Family History of Balkan Endemic Nephropathy

Autor: Mirza Atic, Mirna Aleckovic-Halilovic, Enisa Mesic, Vildana Habul, Maida Dugonjic, Senaid Trnacevic, Emir Hodzic, Evlijana Hasanović
Rok vydání: 2014
Předmět:
Zdroj: International Journal of Nephrology, Vol 2014 (2014)
International Journal of Nephrology
ISSN: 2090-2158
2090-214X
DOI: 10.1155/2014/284293
Popis: Aim. The aim of this study was to compare urinary alpha 1 microglobulin (A1MG) in healthy individuals with and without family burden for Balkan endemic nephropathy (BEN) in an endemic village.Methods. Otherwise healthy inhabitants with microalbuminuria or proteinuria were divided into two groups: with (n=24) and without (n=32) family BEN burden and screened for urinary A1MG and A1MG/urine creatinine ratio.Results. Average value of urinary A1MG was10.35±7.01 mg/L in group with and10.79±8.27 mg/L in group without family history for BEN (NS,P=0.87). A1MG was higher than 10 mg/L in eight (33.33%) inhabitants with family history and in 12 (37.5%) without (NS,P=0.187). Average values of urinary A1MG/creatinine ratio were1.30±1.59and0.94±0.78in group with and group without family BEN history (NS,P=0.39, resp.). Elevated values of this ratio were found in 13 (54.17%) inhabitants with and 14 (43.75%) without family history for BEN (NS,P=0.415).Conclusion. We did not find statistically significant difference in the examined markers between healthy individuals with and without family burden for BEN. We concluded that these markers are not predictive of risk for BEN.
Databáze: OpenAIRE
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