Unusual association of COVID-19, pulmonary tuberculosis and human immunodeficiency virus, having progressed favorably under treatment with chloroquine and rifampin
| Autor: | F. Bouaré, Houssine Ghannane, Imane Saidi, Farouk Hajhouji, Mehdi Laghmari, Lamyae Amro, Felicité Nyafame Etouche, Said Ait Benali, Badr Arjdal, Noura Tassi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Miliary tuberculosis Tuberculosis 030231 tropical medicine Case Report medicine.disease_cause anti-tubercular agents Serology 03 medical and health sciences 0302 clinical medicine Chloroquine Internal medicine SARS-ncov-2 medicine 030212 general & internal medicine Coronavirus Lung business.industry HIV COVID-19 General Medicine medicine.disease Clinical trial medicine.anatomical_structure tuberculosis Sputum medicine.symptom business rifampin medicine.drug |
| Zdroj: | The Pan African Medical Journal |
| ISSN: | 1937-8688 |
| Popis: | Infection with the new coronavirus has been declared an international health emergency. Its curative treatment is unknown and is the subject of several clinical trials. In addition, the concomitant association of COVID-19 with tuberculosis and the human immunodeficiency virus, hitherto never described, is potentially fatal. We report the illustrative case of a 32-year-old patient who presented this trifecta of infections and who did well under treatment with chloroquine and anti-mycobacterial drugs. This patient arrived at the ER with respiratory discomfort that had been evolving over a month with symptoms of flu and deterioration of her general condition. A chest CT scan revealed an aspect of lung miliary tuberculosis with isolation of Koch's bacilli in the sputum. A polymerization chain reaction (PCR) was positive for COVID-19 on a nasopharyngeal swab. HIV serology was positive. The course was marked by a spectacular clinical improvement and two negative COVID-19 PCR controls at the end of treatment (at days 9 and 10). Anti-tubercular drugs (especially, rifampin) are powerful enzyme inducers that can reduce the effectiveness of chloroquine in our patient. This therapeutic success may be linked to the effect of anti-tubercular drugs against SARS ncov-2, especially rifampin, inhibiting the formation of messenger RNAs of SARS ncov-2 or to the synergistic effect of chloroquine and rifampin. Researchers should explore the effect of these drugs on SARS ncov-2. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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