Distribution of divalent metal transporter-1 in the monkey basal ganglia
| Autor: | Wei-Yi Ong, James R. Connor, En Huang |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Male
Iron Caudate nucleus Fluorescent Antibody Technique Substantia nigra Basal Ganglia Basal Ganglia Diseases Microscopy Electron Transmission Iron-Binding Proteins Basal ganglia Animals Cation Transport Proteins biology Pars compacta General Neuroscience Putamen digestive oral and skin physiology DMT1 Anatomy Immunohistochemistry Iron Metabolism Disorders Molecular biology Substantia Nigra Macaca fascicularis Subthalamic nucleus Globus pallidus nervous system Blood-Brain Barrier Astrocytes biology.protein Female Caudate Nucleus Ferrocyanides |
| Zdroj: | Neuroscience. 128:487-496 |
| ISSN: | 0306-4522 |
| Popis: | An accumulation of iron occurs in the brain with age, and it is thought that this may contribute to the pathology of certain neurodegenerative diseases, including Parkinson's disease. In this study, we elucidated the distribution of divalent metal transporter-1 (DMT1) in the monkey basal ganglia by immunocytochemistry, and compared it with the distribution of ferrous iron in these nuclei by Turnbull's Blue histochemical staining. We observed a general correlation between levels of DMT1, and iron staining. Thus, regions such as the caudate nucleus, putamen, and substantia nigra pars reticulata contained dense staining of DMT1 in astrocytic processes, and were also observed to contain large numbers of ferrous iron granules. The exceptions were the globus pallidus externa and interna, which contained light DMT1 staining, but large numbers of ferrous iron granules. The thalamus, subthalamic nucleus, and substantia nigra pars compacta contained neurons that were lightly stained for DMT1, but few or no iron granules. The high levels of DMT1 expression in some of the nuclei of the basal ganglia, particularly the caudate nucleus, putamen, and substantia nigra pars reticulata, may account for the high levels of iron in these regions. |
| Databáze: | OpenAIRE |
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