A specific area of olfactory cortex involved in stress hormone responses to predator odors
| Autor: | David P. Olson, Kunio Kondoh, Xiaolan Ye, Zhonghua Lu, Bradford B. Lowell, Linda B. Buck |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Olfactory system Male Telencephalon Corticotropin-Releasing Hormone Hippocampus Escape response Stimulation Biology Article 03 medical and health sciences Corticotropin-releasing hormone chemistry.chemical_compound Mice 0302 clinical medicine Adrenocorticotropic Hormone Corticosterone Escape Reaction medicine Animals Hormone metabolism Instinct Neurons Multidisciplinary Cerebrum Fear Olfactory Pathways Olfactory Perception Hormones Smell 030104 developmental biology medicine.anatomical_structure Olfactory Cortex chemistry Predatory Behavior Odorants Female Neuroscience 030217 neurology & neurosurgery Stress Psychological |
| Popis: | Instinctive reactions to danger are critical to the perpetuation of species and are observed throughout the animal kingdom. The scent of predators induces an instinctive fear response in mice that includes behavioural changes, as well as a surge in blood stress hormones that mobilizes multiple body systems to escape impending danger. How the olfactory system routes predator signals detected in the nose to achieve these effects is unknown. Here we identify a specific area of the olfactory cortex in mice that induces stress hormone responses to volatile predator odours. Using monosynaptic and polysynaptic viral tracers, we found that multiple olfactory cortical areas transmit signals to hypothalamic corticotropin-releasing hormone (CRH) neurons, which control stress hormone levels. However, only one minor cortical area, the amygdalo-piriform transition area (AmPir), contained neurons upstream of CRH neurons that were activated by volatile predator odours. Chemogenetic stimulation of AmPir activated CRH neurons and induced an increase in blood stress hormones, mimicking an instinctive fear response. Moreover, chemogenetic silencing of AmPir markedly reduced the stress hormone response to predator odours without affecting a fear behaviour. These findings suggest that AmPir, a small area comprising |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|