P53 as a prognostic marker for bladder cancer: a meta-analysis and review
| Autor: | Aurelia Bustos, M. Rivas, Cristiane M Nascimento, Francisco J. Martín Fernández, Manolis Kogevinas, Francisco X. Real, Diana Puente, Núria Malats |
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| Rok vydání: | 2005 |
| Předmět: |
Oncology
medicine.medical_specialty Multivariate statistics Pathology Multivariate analysis chemistry.chemical_compound Internal medicine Molecular marker Biomarkers Tumor Medicine Humans Proportional Hazards Models Bladder cancer business.industry Proportional hazards model Hazard ratio medicine.disease Prognosis Logistic Models Reporting bias chemistry Urinary Bladder Neoplasms Meta-analysis Multivariate Analysis Tumor Suppressor Protein p53 business |
| Zdroj: | The Lancet. Oncology. 6(9) |
| ISSN: | 1470-2045 |
| Popis: | Summary Background P53 is the most widely investigated molecular marker in bladder cancer. We aimed to review comprehensively the evidence for use of changes in P53 to predict bladder-cancer recurrence, progression, and mortality. Methods We reviewed 168 publications from 117 studies. Estimates of significance were extracted from association tests, and hazard ratios with 95% CI from actuarial curves and Cox regression analyses. A meta-analysis was done on the studies that applied Cox models. Findings The methods used to assess significance varied widely between studies. 27% (nine of 34) of studies that assessed the prognostic value of P53 overexpression in recurrence by use of multivariate tests showed a significant association. The corresponding values for progression and mortality were 50% (12 of 24) and 29% (ten of 35), respectively. In the studies that used Cox models, the overall risk of recurrence was 1·6 (95% CI 1·2–2·1), of progression was 3·1 (1·9–4·9), and of mortality was 1·4 (1·2–1·7). These findings could be overestimates because of publication and reporting bias. Interpretation After 10 years of research, evidence is not sufficient to conclude whether changes in P53 act as markers of outcome in patients with bladder cancer. |
| Databáze: | OpenAIRE |
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