Modulation of the Expression of the Granulocyte Adhesion Molecule, CR3, by Percutaneous Transluminal Coronary Angioplasty and Contrast Media
| Autor: | C. Pasquier, Juliard J, Feldman Lj, Elbim C, Chollet-Martin S, Himbert D, Steg Pg |
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| Rok vydání: | 1994 |
| Předmět: |
Male
medicine.medical_specialty Neutrophils Arbitrary unit Contrast Media Gene Expression Macrophage-1 Antigen Coronary Disease chemical and pharmacologic phenomena In Vitro Techniques Granulocyte Pharmacology Coronary Angiography Lymphocyte Activation Flow cytometry In vivo Internal medicine medicine Humans Radiology Nuclear Medicine and imaging Angioplasty Balloon Coronary Incubation Whole blood medicine.diagnostic_test Chemistry hemic and immune systems General Medicine Adhesion Middle Aged Flow Cytometry In vitro medicine.anatomical_structure Cardiology Female |
| Zdroj: | Investigative Radiology. 29:313-318 |
| ISSN: | 0020-9996 |
| Popis: | RATIONALE AND OBJECTIVES The effects of percutaneous transluminal coronary angioplasty (PTCA) and iodinated contrast media on the functional state of polymorphonuclear leukocytes (PMN) were determined; the expression of the PMN adhesion molecule, CR3, was assessed. METHODS CR3 expression was measured by flow cytometry in whole blood samples in vivo, before and after PTCA (n = 17) or coronary angiography (n = 16); and in vitro, before and after incubation of PMNs with iodinated contrast media (n = 5). RESULTS CR3 expression (mean +/- standard error of the mean, arbitrary units) decreased significantly after PTCA (221 +/- 25 to 168 +/- 21, P < .005) and coronary angiography (297 +/- 43 to 218 +/- 25, P < .05). In vitro, there was a dose-dependent decrease of CR3 expression and a significant and strong inverse correlation between CR3 expression and the contrast agent concentrations regardless of the type of contrast agent used. CONCLUSIONS These data suggest that PTCA does not activate circulating PMNs, and that contrast media decrease CR3 expression. Whether this is related to the systemic adverse effects of contrast media remains to be clarified. |
| Databáze: | OpenAIRE |
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