Implementation of the new ILAE classification of epilepsies into clinical practice - A cohort study
| Autor: | Wojciech Turaj, Agnieszka Slowik, Radosław Kacorzyk, Magdalena Bosak |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Pediatrics medicine.medical_specialty Adolescent Student Health Services Neurological examination Disease Cohort Studies 03 medical and health sciences Behavioral Neuroscience Epilepsy Young Adult 0302 clinical medicine Seizures medicine Humans Medical history 030212 general & internal medicine Aged Aged 80 and over medicine.diagnostic_test business.industry Data Collection Electroencephalography Middle Aged medicine.disease Neurology Epilepsy syndromes Cohort Etiology Epilepsy Generalized Female Neurology (clinical) Epilepsies Partial business Epileptic Syndromes 030217 neurology & neurosurgery Cohort study |
| Popis: | Purpose Appropriate management of patients with epilepsy requires precise classification of their disease. Implementation of the recent International League Against Epilepsy (ILAE) classification of seizures and epilepsies may affect data on the relative proportions of specific types of seizures or epilepsies and should be tested in everyday practice. The aim of the study was to determine the prevalence of specific epilepsy types, syndromes, and etiologies, as defined by the new ILAE classification, in a large cohort of adult patients with epilepsy. Material and methods The single-center cohort study involved consecutive adult patients with epilepsy seen at the university epilepsy clinic. Information about medical history, neurological examination, neuroimaging, electroencephalography (EEG), genetic tests, epilepsy treatment, and other investigations was collected from medical records and prospectively updated if necessary. Epilepsy types and etiology, as well as epileptic syndromes, were classified according to the new ILAE classifications. Results We studied 653 patients (mean age: 37.2 years, 59.9% were women). Epilepsy was classified as focal in 458 cases (70.2%), generalized in 155 subjects (23.7%), or as combined focal and generalized in 11 patients (1.7%). The epilepsy type was labeled as unknown in 29 (4.4%) patients. A definite cause of epilepsy was identified in 59.4% of the cases, with a structural etiology (n = 179, 27.4%) and genetic or presumed genetic etiology (n = 169, 25.9%) being the most common. In 167 (25.5%) patients, specific epilepsy syndromes, mostly genetic generalized epilepsy syndromes, were diagnosed. Conclusion The use of the recent ILAE classification of seizures and epilepsies in the cohort of patients with epilepsy seen in single epilepsy center enabled unequivocal characterization of epilepsy type in > 95% of patients. A definite etiology of epilepsy could be established in about 60% of patients. |
| Databáze: | OpenAIRE |
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