Progression of atypical extraventricular neurocytoma to anaplastic ganglioglioma
| Autor: | Olufemi Ajani, Boleslaw Lach, Sheila K. Singh, Daniel Rusiecki, Branavan Manoranjan, Adam Fleming |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Malignant Brain Neoplasm
Pathology medicine.medical_specialty Neoplasm Residual Time Factors Biopsy Brain tumor Pathology and Forensic Medicine Ganglioglioma 03 medical and health sciences 0302 clinical medicine Fatal Outcome Thalamus medicine Biomarkers Tumor Brain Stem Neoplasms Humans Neurocytoma Child Cell Proliferation Glial fibrillary acidic protein biology Chromogranin A Infant medicine.disease Immunohistochemistry Magnetic Resonance Imaging Cell Transformation Neoplastic 030220 oncology & carcinogenesis Anaplastic Ganglioglioma biology.protein Synaptophysin Cancer research Disease Progression Female 030217 neurology & neurosurgery |
| Zdroj: | Human pathology. 59 |
| ISSN: | 1532-8392 |
| Popis: | We report a childhood case of thalamic atypical extraventricular neurocytoma that progressed to highly anaplastic ganglioglioma after 8 years of dormancy after subtotal resection and chemotherapy. The neurocytoma displayed immunoreactivity only for synaptophysin, β-catenin, S100, and CD56. The ganglioglioma acquired strong immunoreactivity for chromogranin, glial fibrillary acidic protein, neuron-specific enolase, and p53 and showed a very high proliferation rate approaching 50% in some areas. Tumor transformation was associated with overexpression of components of the sonic hedgehog and Wnt developmental signaling pathways, which are known to regulate tumor-initiating cells in malignant brain neoplasms. |
| Databáze: | OpenAIRE |
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