Multiple squamous cell carcinomas involving the cervix, vagina, and vulva: the theory of multicentric origin
| Autor: | Stewart L. Marcus |
|---|---|
| Rok vydání: | 1960 |
| Předmět: |
Pathology
medicine.medical_specialty Vaginal Neoplasms Vomiting business.industry Uterine Cervical Neoplasms Obstetrics and Gynecology Vaginal neoplasm medicine.disease Vulva Lesion medicine.anatomical_structure Neoplasms Carcinoma Squamous Cell Etiology medicine Vagina Carcinoma Humans Female Vagina neoplasm medicine.symptom business Cervix |
| Zdroj: | American Journal of Obstetrics and Gynecology. 80:802-812 |
| ISSN: | 0002-9378 |
| DOI: | 10.1016/0002-9378(60)90593-7 |
| Popis: | 1. 1. The case histories of 7 patients, each of whom was treated for primary squamous cell carcinomas of the cervix and the vulva, are reported. One of these patients also presented a third primary lesion, a squamous cell carcinoma of the vagina. In another of these patients, a carcinoma of the vagina was noted whose primary nature was strongly suggested but could not be proved. 2. 2. The concept of multicentricity of origin of carcinoma within an epithelial field bearing a neoplastic potential is discussed. Consideration is given to the experimental and clinical evidence which is incompatible with a unicentric origin of certain neoplasms. 3. 3. The possible role of irradiation in the etiology of multiple neoplasms is discussed in view of other reports and the fact that 4 of the 7 patients in this group presented a carcinoma of the vulva subsequent to irradiation for cervical carcinoma. 4. 4. The problem of late “recurrence” of carcinoma after adequate treatment and apparent cure of cervical carcinoma in situ is considered. Emphasis is given to the possibility that the vaginal lesion may not be a true recurrence but instead a new or a continuing malignant growth in a residual area of a predisposed epithelial field. 5. 5. The gynecologist, encountering a lesion of the cervix, vagina, or vulva, must be cognizant of the potential of multicentric neoplastic change in this large epithelial field. In treating a lesion in one area, he must exclude neoplastic activity in other areas of the field. If none is detected in other areas, he must nevertheless be aware in his follow-up of the patient that this sensitized or predisposed field may subsequently demonstrate malignant change. |
| Databáze: | OpenAIRE |
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