Stereotactic body radiotherapy for oligometastatic prostate cancer recurrence: a meta-analysis
| Autor: | Anielle Freitas Bendo Danelichen, Ana Carolina Hamamura, Alexandre Ciuffi Faustino, Gustavo Arruda Viani, Caio Viani Arruda, F.S. Guimarães |
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| Přispěvatelé: | Universidade de São Paulo (USP), Universidade Estadual Paulista (Unesp) |
| Rok vydání: | 2020 |
| Předmět: |
Male
Cancer Research medicine.medical_specialty recurrence medicine.medical_treatment Urology Cochrane Library Adenocarcinoma Radiosurgery Effective dose (radiation) 03 medical and health sciences Prostate cancer 0302 clinical medicine medicine Biomarkers Tumor Humans 030212 general & internal medicine Univariate analysis business.industry Prostatic Neoplasms medicine.disease prostate cancer oligometastases Confidence interval RADIOTERAPIA Radiation therapy Oncology stereotactic body radiotherapy 030220 oncology & carcinogenesis Meta-analysis Toxicity Neoplasm Recurrence Local business |
| Zdroj: | Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP Scopus Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP |
| Popis: | Made available in DSpace on 2020-12-12T01:13:00Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-02-01 Purpose:The purpose of this study was to evaluate the treatment efficacy of stereotactic body radiotherapy (SBRT) in oligometastatic prostate cancer recurrence and to assess whether there is any relationship between biologically effective dose (BED) and local control (LC).Materials and Methods:Eligible studies were identified on Medline, Embase, and the Cochrane Library, and the proceedings of annual meetings through May 2019 were also identified. A meta-regression analysis was performed to assess whether there is a relationship between BED and LC. In the univariate analysis, studies were separated by the study design, the number of metastatic sites, the site of metastases, radiotherapy machine, and prostate-specific antigen level at the time of SBRT. A P-value 130 Gy3), a significant difference was observed between BED100 Gy3 (LC=96%). The rate of any acute and late grade ≥2 toxicity was 1.3% and 1.2%, respectively.Conclusions:The LC rate with SBRT was excellent with minimal severe acute/late toxicity. Our data suggest a dose relationship between BED and LC, with BED >100 Gy3 resulting in better rates of LC. School of Medicine of Ribeirão Preto University of São Paulo (FMRP-USP) Bioscience Institute University of State from Sao Paulo (UNESP) Bioscience Institute University of State from Sao Paulo (UNESP) |
| Databáze: | OpenAIRE |
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