99mTc-labeled monosaccharide kits: development methods and quality control

Autor: V. L. Sadkin, Viktor Sкuridin, A. S. Rogov, Evgeny Nestеrov, Roman Zelchan, N. V. Varlamova, E. S. Stasyuk
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
ISSN: 2045-2322
Popis: The paper presents the procedure for planning an experiment to create standard sets of reagents for a technetium-99m generator based on glucose derivatives. All stages are presented from researching the required quantities of a substance, a reducing agent, a stabilizer and auxiliary components to developing lyophilized kits and conducting quality control. The radiochemical purity of radiopharmaceuticals prepared on the basis of the developed kits ranged from 90.0 to 99.0%. We also showed the functional suitability of the developed preparations on C57B1/6j mice with an implanted malignant tumor - Lewis lung carcinoma.
Databáze: OpenAIRE
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