Prevalence of the apolipoprotein E E4 allele in amyloid B positive subjects across the spectrum of Alzheimer's disease
| Autor: | Dong Young Lee, Vincent Camus, Sudesh Prabhakar, Anne M. Fagan, Aleksandra Klimkowicz-Mrowiec, Julius Popp, Frans R.J. Verhey, Victor L. Villemagne, David J. Brooks, Susan M. Landau, Kewei Chen, Johannes Kornhuber, Duk L. Na, Linda J C van Waalwijk van Doorn, Mony J. de Leon, Ann D. Cohen, Charlotte E. Teunissen, Eloy Rodríguez-Rodríguez, Erik Stomrud, Philip Scheltens, Wiesje M. van der Flier, Adrian Ivanoiu, Anders Wallin, Eckart Rüther, Adam S. Fleisher, Isabel Santana, Ramesh Kandimalla, Tormod Fladby, Åsa K. Wallin, Peter Johannsen, Stefan Förster, Sang W. Seo, Gaël Chételat, Koen Van Laere, Ina S. Almdahl, Mark M. Mintun, Dag Aarsland, Sanna-Kaisa Herukka, Harald Hampel, Magda Tsolaki, Henrik Zetterberg, Kristian Steen Frederiksen, John C. Morris, David A. Wolk, Marie Sarazin, Hilkka Soininen, Catherine M. Roe, Sebastiaan Engelborghs, Juha O. Rinne, Hanne Struyfs, Daniel Alcolea, Pieter Jelle Visser, Oliver Peters, Willemijn J. Jansen, Alberto Lleó, Bart N.M. van Berckel, Kiran Dip Gill, Arto Nordlund, Jens Wiltfang, Kaj Blennow, Timo Grimmer, Johannes Schröder, Pauline Aalten, Colin Groot, Pascual Sánchez-Juan, Jan Marcusson, Inês Baldeiras, Mark A. van Buchem, Niklas Mattsson, Christopher C. Rowe, Rik Ossenkoppele, Wolfgang Maier, Agneta Nordberg, Rik Vandenberghe, William E. Klunk, Hanne M. Møllergård, José Luis Molinuevo, Stephanie J.B. Vos, Olymbia Gkatzima, Alexander Drzezga, Oskar Hansson, Lorena Rami, Giovanni B. Frisoni, Karen M. Rodrigue, Olga Meulenbroek, Barbara Mroczko, Marcel M. Verbeek, Juan Fortea, Gil D. Rabinovici, William J. Jagust, Yvonne Freund-Levi, Luiza Spiru, Gunhild Waldemar, Catarina R. Oliveira, Enrica Cavedo |
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| Přispěvatelé: | RS: MHeNs - R1 - Cognitive Neuropsychiatry and Clinical Neuroscience, Psychiatrie & Neuropsychologie, MUMC+: MA Med Staf Spec Psychiatrie (9), Frisoni, Giovanni, Popp, Julius, Neurology, Amsterdam Neuroscience - Neurodegeneration, Laboratory Medicine, Radiology and nuclear medicine, APH - Personalized Medicine, APH - Methodology |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Apolipoprotein E Male NATIONAL INSTITUTE Neurology Epidemiology Apolipoprotein E4 LONGITUDINAL COHORT Disease metabolism [Cognitive Dysfunction] ddc:616.89 0302 clinical medicine Prevalence Geographical location genetics [Apolipoprotein E4] APOE GENOTYPE Health Policy GLUCOSE-METABOLISM CEREBROSPINAL-FLUID BIOMARKERS Alzheimer's disease Disorders of movement Donders Center for Medical Neuroscience [Radboudumc 3] 3. Good health Europe Psychiatry and Mental health cerebrospinal fluid [Biomarkers] Biomarker (medicine) lipids (amino acids peptides and proteins) Female Sex ASSOCIATION WORKGROUPS metabolism [Alzheimer Disease] APOE medicine.medical_specialty Amyloid CSF BIOMARKERS metabolism [Amyloid beta-Peptides] CSF ta3112 Education 03 medical and health sciences Cellular and Molecular Neuroscience Age Developmental Neuroscience Alzheimer Disease Internal medicine mental disorders medicine Dementia Humans Cognitive Dysfunction ddc:610 Allele OLDER-ADULTS Biology Alleles Aged Amyloid beta-Peptides business.industry Mild cognitive impairment medicine.disease nervous system diseases 030104 developmental biology Endocrinology PET Positron-Emission Tomography ddc:618.97 Subjective cognitive decline DIAGNOSTIC GUIDELINES Human medicine Neurology (clinical) Geriatrics and Gerontology business 030217 neurology & neurosurgery Biomarkers |
| Zdroj: | Alzheimer's & Dementia, 14(7), 913-924. Elsevier Science Alzheimer's & Dementia, 14, 7, pp. 913-924 Alzheimer's & Dementia Alzheimers & Dementia Alzheimer's & Dementia, Vol. 14, No 7 (2018) pp. 913-924 Alzheimer's and dementia 14(7), 913-924 (2018). doi:10.1016/j.jalz.2018.02.009 Alzheimer's & Dementia, 14, 913-924 r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau instname Alzheimer's and Dementia, 14(7), 913-924 Alzheimer's and Dementia, 14(7), 913-924. Elsevier Alzheimer's & dementia Mattsson, N, Groot, C, Jansen, W J, Landau, S M, Villemagne, V L, Engelborghs, S, Mintun, M M, Lleo, A, Molinuevo, J L, Jagust, W J, Frisoni, G B, Ivanoiu, A, Chételat, G, Resende de Oliveira, C, Rodrigue, K M, Kornhuber, J, Wallin, A, Klimkowicz-Mrowiec, A, Kandimalla, R, Popp, J, Aalten, P P, Aarsland, D, Alcolea, D, Almdahl, I S, Baldeiras, I, van Buchem, M A, Cavedo, E, Chen, K, Cohen, A D, Förster, S, Fortea, J, Frederiksen, K S, Freund-Levi, Y, Gill, K D, Gkatzima, O, Grimmer, T, Hampel, H, Herukka, S K, Johannsen, P, van Laere, K, de Leon, M J, Maier, W, Marcusson, J, Meulenbroek, O, Møllergård, H M, Morris, J C, Mroczko, B, Nordlund, A, Prabhakar, S, Peters, O, Rami, L, Rodríguez-Rodríguez, E, Roe, C M, Rüther, E, Santana, I, Schröder, J, Seo, S W, Soininen, H, Spiru, L, Stomrud, E, Struyfs, H, Teunissen, C E, Verhey, F R J, Vos, S J B, van Waalwijk van Doorn, L J C, Waldemar, G, Wallin, Å K, Wiltfang, J, Vandenberghe, R, Brooks, D J, Fladby, T, Rowe, C C, Drzezga, A, Verbeek, M M, Sarazin, M, Wolk, D A, Fleisher, A S, Klunk, W E, Na, D L, Sánchez-Juan, P, Lee, D Y, Nordberg, A, Tsolaki, M, Camus, V, Rinne, J O, Fagan, A M, Zetterberg, H, Blennow, K, Rabinovici, G D, Hansson, O, van Berckel, B N M, van der Flier, W M, Scheltens, P, Visser, P J & Ossenkoppele, R 2018, ' Prevalence of the apolipoprotein E ε4 allele in amyloid β positive subjects across the spectrum of Alzheimer's disease ', Alzheimer's and Dementia, vol. 14, no. 7, pp. 913-924 . https://doi.org/10.1016/j.jalz.2018.02.009 |
| ISSN: | 1552-5260 |
| DOI: | 10.1016/j.jalz.2018.02.009 |
| Popis: | Introduction: Apolipoprotein E (APOE) epsilon 4 is the major genetic risk factor for Alzheimer's disease (AD), but its prevalence is unclear because earlier studies did not require biomarker evidence of amyloid beta(A beta) pathology. Methods: We included 3451 A beta+ subjects (853 AD-type dementia, 1810 mild cognitive impairment, and 788 cognitively normal). Generalized estimating equation models were used to assess APOE epsilon 4 prevalence in relation to age, sex, education, and geographical location. Results: The APOE epsilon 4 prevalence was 66% in AD-type dementia, 64% in mild cognitive impairment, and 51% in cognitively normal, and it decreased with advancing age in A beta+ cognitively normal and A beta+ mild cognitive impairment (P |
| Databáze: | OpenAIRE |
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