Studies of LDL particle size and susceptibility to oxidation and association with glucose metabolism in children after heart transplantation
| Autor: | Terho Lehtimäki, Christer Holmberg, Marja Ala-Houhala, Marjatta Antikainen, Tiina Solakivi, Matti K. Salo, Hannu Jokela, Arja Siirtola |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Blood Glucose
Male medicine.medical_treatment 030204 cardiovascular system & hematology chemistry.chemical_compound 0302 clinical medicine Hyperinsulinemia Insulin Child 2. Zero hunger 0303 health sciences Glucose tolerance test medicine.diagnostic_test 3. Good health Lipoproteins LDL Cholesterol Child Preschool Female lipids (amino acids peptides and proteins) Cardiology and Cardiovascular Medicine Oxidation-Reduction Adult Pulmonary and Respiratory Medicine medicine.medical_specialty Adolescent 03 medical and health sciences Internal medicine medicine Humans Particle Size Apolipoproteins A Triglycerides Apolipoproteins B 030304 developmental biology Immunosuppression Therapy Transplantation Triglyceride business.industry Hypertriglyceridemia Glucose Tolerance Test medicine.disease Cross-Sectional Studies Endocrinology chemistry Case-Control Studies Heart Transplantation Surgery business Lipoprotein |
| Zdroj: | The Journal of Heart and Lung Transplantation. 23:418-426 |
| ISSN: | 1053-2498 |
| Popis: | Increased concentrations of serum triglyceride and low-density lipoprotein (LDL) cholesterol are common after heart transplantation (HTx). These abnormalities may promote transplant vascular disease and atherosclerosis, especially if LDL is small, dense, and oxidized. There have been no previous studies of LDL particle size and LDL susceptibility to oxidation in children after HTx.Twenty-three HTx recipients (aged 3-19 years) who received triple-drug immunosuppression therapy after HTx and 181 controls within the same age range participated in the study. Total, high-density lipoprotein, and LDL-cholesterol concentrations; triglyceride concentration, and glucose and insulin concentrations during oral glucose tolerance tests were determined an average of 3 years after HTx (range, 1-7 years). Moreover, we determined serum lipoprotein (a) concentration, apolipoprotein E phenotype, LDL particle size, and indices of LDL susceptibility to copper-induced oxidation in 12 HTx recipients.We found hypertriglyceridemia in 56.5% and hyperinsulinemia in 30.4% of patients. Triglyceride concentration and body mass index were associated significantly with insulin concentration (p0.008 for both). Low-density lipoprotein particle size, LDL susceptibility to in vitro oxidation, and lipoprotein (a) concentrations did not differ significantly between HTx patients and controls. Low-density lipoprotein particle size was associated inversely with cyclosporine through level (Neoral, r = -0.59, p = 0.045), whereas weight-adjusted dosage of cyclosporine correlated positively with longer lag time of LDL oxidation (r = 0.69, p = 0.013).Hypertriglyceridemia and hyperinsulinemia were common in children receiving triple-drug immunosuppression therapy after HTx. Increased cyclosporine through concentration was associated with small LDL particle size but did not increase LDL susceptibility to oxidation. |
| Databáze: | OpenAIRE |
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