Bone structural changes in osteoarthritis as a result of mechanoregulated bone adaptation: a modeling approach
| Autor: | van B Bert Rietbergen, Keita Ito, Lge Lieke Cox, van Cc René Donkelaar |
|---|---|
| Přispěvatelé: | Orthopaedic Biomechanics |
| Rok vydání: | 2011 |
| Předmět: |
Cartilage
Articular Pathology medicine.medical_specialty Biomedical Engineering Bone architecture Articular cartilage Osteoarthritis Bone and Bones Bone remodeling Rheumatology Humans Medicine Orthopedics and Sports Medicine skin and connective tissue diseases Cartilage degeneration business.industry Cartilage Computer simulation Mechanoregulation medicine.disease Adaptation Physiological Remodeling Biomechanical Phenomena medicine.anatomical_structure Subchondral bone Eburnation Bone Remodeling sense organs Bone adaptation business Algorithms |
| Zdroj: | Osteoarthritis and Cartilage, 19(6), 676-682. W.B. Saunders Ltd |
| ISSN: | 1063-4584 |
| DOI: | 10.1016/j.joca.2011.02.007 |
| Popis: | Objective There are strong indications that subchondral bone may play an important role in osteoarthritis (OA), making it an interesting target for medical therapies. The subchondral bone structure changes markedly during OA, and it has long been assumed that this occurs secondary to cartilage degeneration. However, for various conditions that are associated with OA, it is known that they may also induce bone structural changes in the absence of cartilage degeneration. We therefore aimed to investigate if OA bone structural changes can result from mechanoregulated bone adaptation, independent of cartilage degeneration. Method With a bone adaptation model, we simulated various conditions associated with OA –without altering the articular cartilage– and we evaluated if mechanoregulated bone remodeling by itself could lead to OA-like bone structural changes. Results For each of the conditions, the predicted changes in bone structural parameters (bone fraction, trabecular thickness, trabecular number, and trabecular separation) were similar to those observed in OA. Conclusion This indicates that bone adaptation in OA can be mechanoregulated with structural changes occurring independent of cartilage degeneration. Keywords: Osteoarthritis; Bone architecture; Computer Simulation; Remodeling; Mechanoregulation |
| Databáze: | OpenAIRE |
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