COMPARISON OF THE CARDIORESPIRATORY EFFECTS OF KETOROLAC AND ALFENTANIL DURING PROPOFOL ANAESTHESIA
| Autor: | A.W. Murray, G.N.C. Kenny, M.S. Brockway |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
Male
Mean arterial pressure Time Factors Respiratory rate Ketorolac Tromethamine Heart rate medicine Humans Tolmetin Tromethamine Alfentanil Propofol business.industry Respiration Anti-Inflammatory Agents Non-Steroidal Hemodynamics Middle Aged Ketorolac Drug Combinations Anesthesiology and Pain Medicine Blood pressure Anesthesia Anesthesia Intravenous Female business medicine.drug |
| Zdroj: | British Journal of Anaesthesia. 63:601-603 |
| ISSN: | 0007-0912 |
| DOI: | 10.1093/bja/63.5.601 |
| Popis: | The cardiorespiratory effects of a new nonopioid analgesic, ketorolac tromethamine, were compared with alfentanil as part of a balanced technique in which anaesthesia was maintained by a constant infusion of propofol. Twenty patients were allocated randomly to receive a single dose of either ketorolac 30 mg or alfentanil 0.5 mg. The study medication was given during the anaesthetic when the rate of ventilation had been stable (+/- 1 b.p.m.) for 5 min. Measurements of ventilatory rate, end-tidal carbon dioxide partial pressure, arterial oxygen saturation (SaO2), heart rate and systemic arterial pressure were made at 1-min intervals for 15 min following the test drug. Patients having alfentanil developed significant decreases in ventilatory rate, heart rate and mean arterial pressure. A significant increase in end-tidal carbon dioxide partial pressure occurred also. No changes occurred in any of the measured variables in the ketorolac group. |
| Databáze: | OpenAIRE |
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